Fig. 4

ROC curve of a resected specimen and biopsy specimen. The differential diagnostic performance based on the IMP3-positive rate was calculated as the ROC curve; specifically, patients with adenoma/adenocarcinoma (without infiltrating adenocarcinoma into the sphincter of Oddi) were indicated for localized resection and those with adenocarcinoma with invasion deeper than the sphincter of Oddi were not indicated for such a procedure, respectively. a The resected specimen AUC was 0.8. When the cutoff was set at 10%, the sensitivity was 73.3%, specificity was 90%, and accuracy was 80%. b The biopsy specimen AUC was 0.78. When the cutoff was set at 10%, the sensitivity was 70%, specificity was 78.6%, and accuracy was 75%. IMP3 insulin-like growth factor 2 messenger RNA–binding protein 3