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Table 1 Evolution of liver and coagulation indices before and after CDCA

From: Successful treatment of infantile oxysterol 7α-hydroxylase deficiency with oral chenodeoxycholic acid

 

Pretreatment

Starting CDCA treatment

15 days after treatment

1 months after treatment

4 months after treatment

8 months after treatment

1 year–8 months after treatment

ALT (7–40U/L)

133

127

127

104

74.9

47.4

24.6

AST (13–35U/L)

206

129

115

122

64.2

47.7

35.5

TBIL (5–21 μmol/L)

300

183

119.4

67.6

6

5.2

4.7

DBIL (0–3.4 μmol/L)

150.4

78

54.5

29.2

2.9

2.1

1.6

TBA (0–10 μmol/L)

100.9a

33.6b

54.5

65.2

12.8

4

4.9

ALP (35–135U/L)

974

742

509

536

186

236

197

γ-GT (7–45U/L)

27

26

94

183

132.7

34.1

18.4

ALB (35–45 g/L)

33

31

37

35

46.7

46.2

44.5

PT (9–12.5S)

29

19.7

17.3

15.5

11

12.8

13.3

APTT (25.4–38.4S)

75.1

47.8

46

37.9

41.7

35

34.2

INR (0.77–1.25)

2.59

1.75

1.51

1.35

0.94

0.93

1

FIB (2.38–4.98 g/L)

1.42

0.98

1.49

3.33

1.64

2.13

2.16

  1. ALT alkaline aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin, DBIL direct bilirubin, TBA total bile acids, ALP alkaline phosphatase, γ-GT γ-glutamyltransferase, ALB albumin, PT prothrombin time, APTT activated partial thromboplastin time, INR international normalized ratio, FIB fibrinogen
  2. aThe value during the administration of UDCA
  3. bTBA level significantly decreased after UDCA stopped