Fig. 4

Correlation between liver-specific cfDNA levels and alkaline phosphatase in PBC and PSC patients. Alkaline phosphatase levels were correlated with liver-specific cfDNA as measured at all 3 genes: IGF2R, ITIH4 and VTN in a PBC patients and b PSC patients but not in c controls. d Total bilirubin levels were not correlated with liver-specific cfDNA levels in PSC patients. Data presented as a plot of alkaline phosphatase expressed as times the upper limit of normal (ALP x ULN) or Bilirubin, Total versus cfDNA values expressed as genomic equivalents per ml (Geq/ml), with linear regression line and 95% confidence interval shown. Correlation was evaluated using the Pearson correlation coefficient (r)