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Table 1 Clinical features of NK/T-cell EBV-associated LPD manifested as gastrointestinal symptoms

From: Clinical features of NK/T-cell EBV-associated LPD manifested as gastrointestinal symptoms in patients with normal immunity: a case report and literature review

References Country Number of case Age/sex DCBC Initial symptoms Treatment history Affected sites Complications Misdiagnosis Endoscopic findings Confirmation approach Treatment
Shen et al. [4] China 1 26/M 1 year Diarrhea, fever Ant anti-TB therapy Colon TB Superficial ulcer, erythema, erosion Lymph node biopsy GLIDE
Shen et al. [4] China 2 21/M 1 year Diarrhea, fever Antibiotics NS Intestinal infection NS Lymph node biopsy Sodium phosphonate, interferon, prednisone
Chen et al. [13] China 3 29/M 1 year Diarrhea, abdominal pain Methylprednisolone and mesalazine, methyl-prednisolone, anti-TNF treatment Esophagus, stomach, IC and the entire colon Perforation CD Multiple ulcers Surgery CHOP
Na et al. [3] Korea 4 50/M 8 years Loose stools Antituberculous medication IC,SC and rectum, jejunum Perforation TB Multiple multiform ulcers Endoscopy CHOP
Na et al. [3] Korea 5 49/F 19 months Hematochezia Prednisolone, azathioprine IC, AC Perforation CD Multiple well-demarcated circumferential or geographic ulcer Endoscopy DHAP
Zhu and Tang [14] China 6 47/M 9 months Diarrhea, fever Anti-TB therapy IC TB Multiple circumferential or geographic ulcer Endoscopy Thalidomide, Anflon, prednisone
Xiao et al. [15] China 7 14/M 9 months Abdominal pain, diarrhea, intermittent fever, hematochezia Mesalazine and prednisone IC, AC Perforation IBD Ulcers and erosions Surgery Surgery
Furuya et al. [16] China 8 49/F 44 months Diarrhea and abdominal pain 5-Aminosalicylate IC CD Longitudinal ulcers Endoscopy SMILE
Abdul-Ghafar et al. [7] Korea 9 45/M 45 days Diarrhea, weight loss metronidazole IC, AC, TC, DC, SC, rectum Hematochezia Infectious colitis Multiple, variable sized, irregular shallow ulcerations Endoscopy
Wang et al. [5] China 10 54/M 5 years Abdominal pain, haematochezia, fever 5-ASA, GC AC, TC, DC, SC Perforation, haemorrhage UC, CD MIVUs including a longitudinal ulcer Surgery
Wang et al. [5] China 11 31/F 10 years Abdominal pain, haematochezia, fever 5-ASA, GC Colorectum Haemorrhage and HLH UC Diffuse inflammation, sporadic small ulcers Surgery GLIDE,HSCT
Wang et al. [5] China 12 24/F 3 months Haematochezia, fever Anti-TB therapy IC, AC, SC, rectum TB MIVUs Endoscopy GLIDE
Wang et al. [5] China 13 49 M 1 year Abdominal pain, weight loss 5-ASA, IFX [four times] IC Perforation CD Isolated annular ulcer Endoscopy
Wang et al. [5] China 14 40/M 3 years Abdominal pain, haematochezia, fever 5-ASA IC and whole colorectum UC Diffuse inflammation, sporadic ulcers Endoscopy GLIDE
Wang et al. [5] China 15 35/M 3 years Abdominal pain, haematochezia, fever AC, TC, SC Perforation CD Multiple irregular ulcers Surgery
Wang et al. [5] China 16 47/M 9 months Diarrhea, fever Anti-TB therapy IC, AC, TC, DC, SC, rectum TB MIVUs including one transverse ulcer Endoscopy GLIDE
Wang et al. [5] China 17 30/F 2 years Abdominal pain, diarrhea, fever 5-ASA, Anti-TB therapy TC, rectum UC, CD Two irregular [both transverse-like] ulcers Endoscopy GLIDE
Wang et al. [5] China 18 39/F 4 years Haematochezia, fever IC, AC, TC, DC Perforation MIVUs including one transverse ulcer Endoscopy LVD
Wang et al. [5] China 19 53/F 9 months Abdominal pain, diarrhea, fever 5-ASA, GC IC, AC, TC, DC, SC CD MIVUs including one transverse ulcer Endoscopy
Wang et al. [5] China 20 34/F 5 months Abdominal pain, haematochezia, fever Ileum Perforation, obstruction CD Multiple round ulcers Surgery
Wang et al. [5] China 21 29/M 3 months Abdominal pain, haematochezia, fever Anti-TB therapy IC, AC, DC, SC Perforation TB MIVUs including one transverse ulcer Endoscopy
Sazuka et al. [17] Japan 22 71/F 3 months Diarrhea Small intestine Flattened villi Endoscopy CHOP
Wang et al. [6] China 23 26/M 1 year Diarrhea and abdominal pain IFX [five times] IC, AC, TC, DC, SC CD Multiple nodular hyperplasia, deep ulcers Endoscopy CHOP
Our case China 24 30/M 5 years Fever and diarrhea Ethyl-prednisolone, thalidomide and mesalazine IC, TC CD MIVUs Endoscopy Thalidomide