Table 1 Baseline demographic and clinicopathologic characteristics in the construction and validation cohort
From: Nomogram for predicting overall survival in colorectal cancer with distant metastasis
Subject characteristics | Construction cohort (N = 7099) | Validation cohort (N = 7098) | ||
|---|---|---|---|---|
Alive (N, %) | Dead (N, %) | Alive (N, %) | Dead (N, %) | |
Age (years, mean = 61.5 ± 13.7; median = 61) | ||||
< 65 | 1679 (67.6) | 2523 (54.7) | 1765 (68.2) | 2433 (53.9) |
≥ 65 | 804 (32.4) | 2093 (45.3) | 823 (31.8) | 2077 (46.1) |
Gender | ||||
Male | 1295 (52.2) | 2487 (53.9) | 1329 (51.4) | 2431 (53.9) |
Female | 1188 (47.8) | 2129 (46.1) | 1259 (48.6) | 2079 (46.1) |
Marital status | ||||
Married | 1494 (60.2) | 2386 (51.7) | 1568 (60.6) | 2372 (52.6) |
Unmarried | 989 (39.8) | 2230 (48.3) | 1020 (39.4) | 2138 (47.4) |
Race | ||||
White | 1885 (75.9) | 3473 (75.2) | 1983 (76.6) | 3436 (76.2) |
Black | 323 (13.0) | 740 (16.0) | 331 (12.8) | 665 (14.7) |
Others | 275 (11.1) | 403 (8.7) | 274 (10.6) | 409 (9.1) |
Insurance | ||||
Insured | 2398 (96.6) | 4357 (94.4) | 2457 (94.9) | 4253 (94.3) |
Uninsured | 85 (3.4) | 259 (5.6) | 131 (5.1) | 257 (5.7) |
Primary site | ||||
Left colon | 1525 (61.4) | 2423 (52.5) | 1610 (62.2) | 2335 (51.8) |
Right colon | 915 (36.9) | 2089 (45.3) | 943 (36.4) | 2056 (45.6) |
Other sites | 43 (1.7) | 104 (2.3) | 35 (1.4) | 119 (2.6) |
Grade | ||||
Grade I | 160 (6.4) | 222 (4.8) | 181 (7.0) | 198 (4.4) |
Grade II | 1792 (72.2) | 2790 (60.4) | 1852 (71.6) | 2787 (61.8) |
Grade III | 445 (17.9) | 1338 (29.0) | 452 (17.5) | 1248 (27.7) |
Grade IV | 86 (3.5) | 266 (5.8) | 103 (4.0) | 277 (6.1) |
CEA | ||||
Normal | 661 (26.6) | 834 (18.1) | 748 (28.9) | 853 (18.9) |
Elevated | 1822 (73.4) | 3782 (81.9) | 1840 (71.1) | 3657 (81.1) |
T stage | ||||
T1 | 140 (5.6) | 513 (11.1) | 154 (6.0) | 493 (10.9) |
T2 | 103 (4.1) | 96 (2.1) | 88 (3.4) | 97 (2.2) |
T3 | 1328 (53.5) | 2034 (44.1) | 1390 (53.7) | 1992 (44.2) |
T4 | 912 (36.7) | 1973 (42.7) | 956 (36.9) | 1928 (42.7) |
N stage | ||||
N0 | 670 (27) | 1159 (25.1) | 703 (27.2) | 1058 (23.5) |
N1 | 1008 (40.6) | 1687 (36.5) | 1066 (41.2) | 1643 (36.4) |
N2 | 805 (32.4) | 1770 (38.3) | 819 (31.6) | 1809 (40.1) |
Bone metastasis | ||||
No | 2434 (98.0) | 4381 (94.9) | 2541 (98.2) | 4282 (94.9) |
Yes | 49 (2.0) | 235 (5.1) | 47 (1.8) | 228 (5.1) |
Brain metastasis | ||||
No | 2468 (99.4) | 4553 (98.6) | 2574 (99.5) | 4457 (98.8) |
Yes | 15 (0.6) | 63 (1.4) | 14 (0.5) | 53 (1.2) |
Liver metastasis | ||||
No | 809 (32.6) | 1290 (27.9) | 887 (34.3) | 1188 (26.3) |
Yes | 1674 (67.4) | 3326 (72.1) | 1701 (65.7) | 3322 (73.7) |
Lung metastasis | ||||
No | 2061 (83.0) | 3580 (77.6) | 2166 (83.7) | 3526 (78.2) |
Yes | 422 (17.0) | 1036 (22.4) | 422 (16.3) | 984 (21.8) |
Surgery for primary site | ||||
No | 379 (15.3) | 1235 (26.8) | 418 (16.2) | 1152 (25.5) |
Yes | 2104 (84.7) | 3381 (73.2) | 2170 (83.8) | 3358 (74.5) |
Radiation | ||||
No/unknown | 2102 (84.7) | 4058 (87.9) | 2189 (84.6) | 3986 (88.4) |
Yes | 381 (15.3) | 558 (12.1) | 399 (15.4) | 524 (11.6) |
Chemotherapy | ||||
No/unknown | 321 (12.9) | 1479 (32) | 305 (11.8) | 1458 (32.3) |
Yes | 2162 (87.1) | 3137 (68) | 2283 (88.2) | 3052 (67.7) |