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Table 1 Baseline demographic and clinicopathologic characteristics in the construction and validation cohort

From: Nomogram for predicting overall survival in colorectal cancer with distant metastasis

Subject characteristics Construction cohort (N = 7099) Validation cohort (N = 7098)
Alive (N, %) Dead (N, %) Alive (N, %) Dead (N, %)
Age (years, mean = 61.5 ± 13.7; median = 61)
 < 65 1679 (67.6) 2523 (54.7) 1765 (68.2) 2433 (53.9)
 ≥ 65 804 (32.4) 2093 (45.3) 823 (31.8) 2077 (46.1)
Gender     
 Male 1295 (52.2) 2487 (53.9) 1329 (51.4) 2431 (53.9)
 Female 1188 (47.8) 2129 (46.1) 1259 (48.6) 2079 (46.1)
Marital status     
 Married 1494 (60.2) 2386 (51.7) 1568 (60.6) 2372 (52.6)
 Unmarried 989 (39.8) 2230 (48.3) 1020 (39.4) 2138 (47.4)
Race     
 White 1885 (75.9) 3473 (75.2) 1983 (76.6) 3436 (76.2)
 Black 323 (13.0) 740 (16.0) 331 (12.8) 665 (14.7)
 Others 275 (11.1) 403 (8.7) 274 (10.6) 409 (9.1)
Insurance     
 Insured 2398 (96.6) 4357 (94.4) 2457 (94.9) 4253 (94.3)
 Uninsured 85 (3.4) 259 (5.6) 131 (5.1) 257 (5.7)
Primary site     
 Left colon 1525 (61.4) 2423 (52.5) 1610 (62.2) 2335 (51.8)
 Right colon 915 (36.9) 2089 (45.3) 943 (36.4) 2056 (45.6)
 Other sites 43 (1.7) 104 (2.3) 35 (1.4) 119 (2.6)
Grade     
 Grade I 160 (6.4) 222 (4.8) 181 (7.0) 198 (4.4)
 Grade II 1792 (72.2) 2790 (60.4) 1852 (71.6) 2787 (61.8)
 Grade III 445 (17.9) 1338 (29.0) 452 (17.5) 1248 (27.7)
 Grade IV 86 (3.5) 266 (5.8) 103 (4.0) 277 (6.1)
CEA     
 Normal 661 (26.6) 834 (18.1) 748 (28.9) 853 (18.9)
 Elevated 1822 (73.4) 3782 (81.9) 1840 (71.1) 3657 (81.1)
T stage     
 T1 140 (5.6) 513 (11.1) 154 (6.0) 493 (10.9)
 T2 103 (4.1) 96 (2.1) 88 (3.4) 97 (2.2)
 T3 1328 (53.5) 2034 (44.1) 1390 (53.7) 1992 (44.2)
 T4 912 (36.7) 1973 (42.7) 956 (36.9) 1928 (42.7)
N stage     
 N0 670 (27) 1159 (25.1) 703 (27.2) 1058 (23.5)
 N1 1008 (40.6) 1687 (36.5) 1066 (41.2) 1643 (36.4)
 N2 805 (32.4) 1770 (38.3) 819 (31.6) 1809 (40.1)
Bone metastasis     
 No 2434 (98.0) 4381 (94.9) 2541 (98.2) 4282 (94.9)
 Yes 49 (2.0) 235 (5.1) 47 (1.8) 228 (5.1)
Brain metastasis     
 No 2468 (99.4) 4553 (98.6) 2574 (99.5) 4457 (98.8)
 Yes 15 (0.6) 63 (1.4) 14 (0.5) 53 (1.2)
Liver metastasis     
 No 809 (32.6) 1290 (27.9) 887 (34.3) 1188 (26.3)
 Yes 1674 (67.4) 3326 (72.1) 1701 (65.7) 3322 (73.7)
Lung metastasis     
 No 2061 (83.0) 3580 (77.6) 2166 (83.7) 3526 (78.2)
 Yes 422 (17.0) 1036 (22.4) 422 (16.3) 984 (21.8)
Surgery for primary site     
 No 379 (15.3) 1235 (26.8) 418 (16.2) 1152 (25.5)
 Yes 2104 (84.7) 3381 (73.2) 2170 (83.8) 3358 (74.5)
Radiation     
 No/unknown 2102 (84.7) 4058 (87.9) 2189 (84.6) 3986 (88.4)
 Yes 381 (15.3) 558 (12.1) 399 (15.4) 524 (11.6)
Chemotherapy     
 No/unknown 321 (12.9) 1479 (32) 305 (11.8) 1458 (32.3)
 Yes 2162 (87.1) 3137 (68) 2283 (88.2) 3052 (67.7)