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Table 1 Baseline characteristics between micro-nutrient deficiency group and non-deficiency group

From: Incidence and risk factors of micronutrient deficiency in patients with IBD and intestinal Behçet’s disease: folate, vitamin B12, 25-OH-vitamin D, and ferritin

Variables Total (n = 205) Micro-nutrient deficiency group (n = 80, 39.0%) Non-deficiency group (n = 125, 61.0%) P-value
Male sex 118 (57.6) 44 (55.0) 74 (59.2) 0.553
Age 34 (19–47) 27 (19–41) 37 (20–51) 0.003
The path of laboratory test     0.150
 Outpatients clinic 191 (93.2) 72 (90.0) 119 (95.2)  
 Hospitalization patients 14 (6.8) 8 (10.0) 6 (4.8)  
Number of micronutrient tests     
 Folate 127 (62.0) 64 (80.0) 63 (50.4)  < 0.001
 Vitamin B12 128 (62.4) 64 (80.0) 64 (51.2)  < 0.001
 25-OH-vitamin D 184 (90.2) 67 (83.8) 117 (94.4) 0.013
 Ferritin 97 (47.3) 48 (60.0) 49 (39.2) 0.004
Type of IBD     0.003
 UC 49 (23.9) 9 (11.3) 40 (32.0)  
 CD 143 (69.8) 66 (82.5) 77 (61.6)  
 Intestinal BD 13 (6.3) 5 (6.3) 8 (6.4)  
Medications     
 5-ASA 114 (55.6) 33 (41.3) 81 (64.8) 0.001
 Steroids 12 (5.9) 3 (3.8) 9 (7.2) 0.305
 Azathioprine 66 (32.2) 32 (40.0) 34 (27.2) 0.056
 Anti-TNF 101 (49.3) 45 (56.3) 56 (44.8) 0.110
 Methotrexate 33 (16.1) 11 (13.8) 22 (17.6) 0.464
 6-MP 2 (1.0) 0 (0) 2 (1.6) 0.256
 Othersa 12 (5.9) 2 (2.5) 10 (8.0) 0.102
Supplementary medications     
 Iron supplementation 77 (37.6) 43 (53.8) 34 (27.2)  < 0.001
 Folate supplementation 50 (24.4) 26 (32.5) 24 (19.2) 0.031
 Multivitamin 52 (25.4) 21 (26.3) 31 (24.8) 0.816
 Calcium, Vitamin D supplementation 127 (62.0) 51 (63.7) 76 (60.8) 0.671
 Vitamin B12 supplementation 43 (21.0) 30 (37.5) 13 (10.4)  < 0.001
 Vitamin C supplementation 3 (1.5) 0 (0) 3 (2.4) 0.163
 Zinc supplementation 7 (3.4) 3 (3.8) 4 (3.2) 0.832
 Osteoporosis medication     
 SERM 3 (1.5) 1 (1.3) 2 (1.6) 0.839
 Bisphosphonate 14 (6.8) 1 (1.3) 13 (10.4) 0.011
Operation 65 (31.7) 33 (41.3) 32 (25.6) 0.019
Underlying disease     
 Hypertension 4 (2.0) 1 (1.3) 3 (2.4) 0.561
 Diabetes 1 (0.5) 0 (0) 1 (0.8) 0.423
 Osteoporosis 38 (18.5) 13 (16.3) 25 (20.0) 0.500
 Othersb 46 (22.4) 19 (23.8) 27 (21.6) 0.719
  1. Data are expressed as median (interquartile range, IQR) or n (%). *P-value for comparing patients with micronutrient deficiency group and non-deficiency group
  2. IBD, Inflammatory bowel disease; UC, Ulcerative colitis; CD, Crohn’s disease; BD, Behçet’s disease; 5-ASA, 5-aminosalicylic acid; anti-TNF, anti-tumor necrosis factor; 6-MP, 6-mercaptopurine; SERM, Selective estrogen receptor modulators
  3. aMongersen, vedolizumab
  4. bMyelodysplastic syndrome, Systemic lupus erythematosus, aortic valve disease, Bronchiolitis obliterans with organizing pneumonia, osteoarthritis, coronary artery occlusive disease, cancer
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