Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis based on the revised Atlanta classification

Table 2 Comparison of clinical biomarkers and scores in different groups

Parameters	Control (n = 10)	Non-SAP (n = 117)	SAP (n = 26)	P value
WBC (× 10⁹/L)	5.52 ± 2.57	12.54 ± 4.58	14.28 ± 3.62	0.166
Neutrophil count (× 10⁹/L)	4.01 ± 2.13	10.12 ± 4.07	12.42 ± 3.21	0.041
Lymphocyte count (× 10⁹/L)	2.13 ± 1.04	1.66 ± 1.73	0.96 ± 0.40	0.115
NLR	3.64 ± 2.14	9.88 ± 6.32	15.76 ± 8.52	0.003
HCT (%)	42.33 ± 3.78	40.26 ± 6.20	37.94 ± 9.69	0.251
BUN (mmol/L)	4.67 ± 2.17	5.09 ± 3.44	11.83 ± 6.74	< 0.001
Cr (umol/L)	67.23 ± 18.55	80.69 ± 25.39	182.03 ± 123.13	< 0.001
D-dimer (mg/L)	0.32 ± 0.21	1.41 ± 1.81	3.85 ± 4.29	0.001
Fibrinogen (g/L)	3.21 ± 0.67	4.99 ± 1.72	5.73 ± 1.60	0.127
CRP (mg/L)	5.32 ± 4.26	151.16 ± 105.05	303.03 ± 222.40	0.017
PCT (ng/L)	0.36 ± 0.12	2.15 ± 5.54	6.33 ± 6.72	0.033
IL-6 (pg/ml)	3.27 ± 2.59	47.39 ± 59.21	183.33 ± 231.23	< 0.001
IL-10 (pg/ml)	8.23 ± 3.12	13.29 ± 31.78	14.41 ± 20.87	0.896
TNF-α (pg/ml)	4.24 ± 2.18	14.08 ± 8.75	17.96 ± 9.24	0.126
MIF (ng/ml)	0.51 ± 0.23	1.68 ± 2.04	6.04 ± 4.05	< 0.001
APACHE II		4.40 ± 3.74	12.19 ± 4.13	< 0.001
BISAP		1.02 ± 0.77	2.94 ± 1.29	< 0.001
SIRS		2.14 ± 2.09	4.50 ± 2.66	< 0.001

The bold in the table means the P value of these parameters were < 0.05 and considered statistically significant
WBC White blood cell, NLR Neutrophil–lymphocyte ratio, HCT Hematocrit, BUN Blood urea nitrogen, Cr Creatinine, CRP C-reactive protein, PCT procalcitonin, IL Interleukin, TNF Tumor necrosis factor, MIF Macrophage migration inhibitory factor, APACHE Acute Physiology And Chronic Health Evaluation, BISAP Bedside Index for Severity in Acute Pancreatitis, SIRS Systemic Inflammatory Response Syndrome
WBC, Neutrophil count, CRP, APACHE II, BISAP and SIRS were expressed as mean ± standard deviation (SD), other variables—as median ± interquartile ranges (IQR)

ISSN: 1471-230X