Fig. 4

Histological findings of extranodal NK/T-cell lymphoma (nasal type) associated with continuously activated EBV infection. a Macroscopic finding of skin ulcer on the patient’s thigh, which occurred more than 4 years after the initiation of medical treatment. b Microscopic finding of H&E staining of the skin ulcer. c Microscopic findings revealed high proliferation of EBER-positive atypical lymphocytes in the diseased skin. d Microscopic finding of H&E staining in the intestinal ulcer. e Microscopic immunohistological findings of ileal ulcerative lesions revealed moderate infiltration of many EBER-positive lymphocytes, which demonstrated continuously active EBV infection