Fig. 3

OCT metabolism by CYP3A in rat intestinal microsomes. CYP3A activity was measured using a fluorescent detection kit, and OCT content was determined at different times by LC–MS/MS. Results are expressed as mean ± S.D. (n = 6). *p < 0.01, Group N + OCT versus Group OCT, Group PH + OCT versus Group OCT; **p < 0.01, Group N + OCT + K versus Group N + OCT; #p < 0.05, Group PH + OCT versus Group N + OCT; ^##p < 0.01, Group PH + OCT + K versus Group PH + OCT. Group OCT, OCT alone without microsomes; N, Normal microsomes; PH, PH microsomes; K, ketoconazole