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Fig. 2 | BMC Gastroenterology

Fig. 2

From: Overexpression of P-glycoprotein, MRP2, and CYP3A4 impairs intestinal absorption of octreotide in rats with portal hypertension

Fig. 2

Effects of P-gp and MRP2 inhibition on the time profile of OCT transport in the intestine. a OCT absorption kinetics in in situ jejunal perfusion experiments in healthy rats; b OCT absorption kinetics in in situ jejunal perfusion experiments in PH rats; c OCT absorption kinetics in the everted intestinal sac preparation in healthy rats; d OCT absorption kinetics in the everted intestinal sac preparation in PH rats; Group A, control group; Group B, OCT plus verapamil hydrochloride; Group C, OCT plus probenecid; Group D, OCT plus verapamil hydrochloride plus probenecid. Results are expressed as mean ± S.D. (n = 4). *p < 0.05 versus control (Group A, Group A1), **p < 0.01 versus control (Group A, Group A1)

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BMC Gastroenterology

ISSN: 1471-230X

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