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Table 6 Predictors of severe fibrosis (stage 3–4) in patients with lean NAFLD

From: Non-invasive predictors of prognosis of Asian patients with histopathologically-confirmed lean nonalcoholic fatty liver disease

 

Univariate

Multivariate

OR

(95% CI)

P value

OR

(95% CI)

P value

Sex

      

 Female

1.8

(0.81–4.00)

0.132

   

 Male

1

     

History of liver cancer

      

 Yes

6.37

(1.86–23.60)

0.001

2.05

(0.37–11.40)

0.411

 No

1

  

1

  

History on non-liver malignancy

      

 Yes

3.01

(0.88–9.93)

0.054

   

 No

1

     

Dyslipidemia

      

 Yes

1.68

(0.72–3.83)

0.220

   

 No

1

     

Hypertension

      

 Yes

1.55

(0.68–3.49)

0.323

   

 No

1

     

Hyperuricemia

      

 Yes

2.37

(0.19–21.56)

0.311

   

 No

1

     

Smoking

      

 No

1.22

(0.46–3.66)

0.821

   

 Yes

1

     

Gamma-glutamyl transpeptidase (IU/L)

      

 < 71

1.35

(0.62–3.00)

0.464

   

 ≥ 71

1

     

Hemoglobin (g/dL)

      

 ≤ 14.5

2.16

(0.97–5.03)

0.045

1.37

(0.43–4.36)

0.594

 > 14.5

1

  

1

  

Ferritin (ng/mL)

      

 ≥ 180

1.16

(0.52–2.61)

0.711

   

 < 180

      

NAFLD fibrosis score

      

 ≥ − 1.455

16.49

(6.43–47.12)

 < 0.01

14.60

(4.50–47.20)

 < 0.01

 < − 1.455

1

  

1

  

PNPLA3 rs738409

      

 GG

3.13

(1.18–8.74)

0.014

1.78

(0.58–5.44)

0.312

 Non GG

1

  

1

  

TM6SF2 rs58542926

      

 Non CC

1.24

(0.41–3.53)

0.802

   

 CC

1

     

HSD17B13 rs6834314

      

 Non AA

1.43

(0.54–3.94)

0.506

   

 AA

1

     
  1. Parameters that correlated significantly with other variables were considered confounding factors and excluded from statistical analysis
  2. P values by logistic regression analysis
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BMC Gastroenterology

ISSN: 1471-230X

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