From: Effects of proton pump inhibitor use on the esophageal microbial community
Patients with PPI use | Patients without PPI use | P-value | |
---|---|---|---|
N | 52 | 6 | |
Barrett’s esophagus | 48% (25/52) | 17% (1/6) | 0.21 |
Male | 56% (29/52) | 17% (1/6) | 0.07 |
Mean age (years) | 60.4 (36—83) | 60.5 (52—68) | 0.99 |
Mean BMI | 30.2 (17.9—40.3) | 30.8 (21.0—38.6) | 0.82 |
Mean weight change (kilograms) | Loss of 0.7 | Loss of 2.8 | 0.44 |
Ethnicity | |||
Caucasian | 79% (41/52) | 83% (5/6) | 0.80 |
Hispanic | 13% (7/52) | 17% (1/6) | |
African American | 6% (3/52) | ||
Asian | 2% (1/52) | ||
Presence of hiatal hernia | 37% (19/52) | 33% (2/6) | 0.88 |
Smoking status | |||
Current | 21% (11/52) | 33% (2/6) | 0.78 |
Past | 35% (18/52) | 33% (2/6) | |
Never | 44% (23/52) | 33% (2/6) | |
Mean PPI dose (milligrams) | 42.7 (20—80) | ||
Mean PPI duration (years) | 2.5 (1—13) |