Skip to main content
Fig. 5 | BMC Gastroenterology

Fig. 5

From: Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model

Fig. 5

Effect of sex hormones and selective ER agonists (PPT, DPN) on Nrf2/nNOS, ERs, and BH4 synthesis enzyme mRNA expression in an in-vitro hyperglycemia model. (a-f) nNOS, Nrf2, ERs and BH4 synthesis enzyme mRNA expression. Gastric neuromuscular tissues incubated with selective ER-agonists for 48 h. (a) nNOSα, (b) Nrf2, (c) GCH-1, (d) DHFR, (e) ERα, and (f) ERβ mRNA expression were measured via RT-qPCR. Data were normalized with housekeeping gene (β-actin). Bar graphs showed a ratio of target gene or protein with β-actin. Data were analyzed using one-way ANOVA by using GraphPad prism software. Data are means ± SEM (n = 4). * p< 0.05 compared with normal glycemia (NG) groups

Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us