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Table 4 Factors at debut of ulcerative colitis in the validation cohort to predict severe treatment outcomes at one year of disease based on cut off values from the discovery cohort

From: Discovery and validation of mucosal TNF expression combined with histological score - a biomarker for personalized treatment in ulcerative colitis

Factors

Youden’s J

Cutt off value

Sensitivity

Specificity

PPV

NPV

DOR

TNFa

0,40

≥18,000

0,50

0,90

0,56

0,87

9

RHIb

0,41

≥9

0,72

0,69

0,38

0,90

6

Combined TNF RHI

0,43

18,000 ≥ 9

0,44

0,99

0,89

0,87

54

  1. DOR Diagnostic odds ratio, PPV Positive predictive value NPV Negative predictive value
  2. a copies/μg mRNA bRobarts histopathology index score
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BMC Gastroenterology

ISSN: 1471-230X

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