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Table 2 Factors at debut of ulcerative colitis in the calibration cohort to predict severe treatment outcomes at one year of disease

From: Discovery and validation of mucosal TNF expression combined with histological score - a biomarker for personalized treatment in ulcerative colitis

Factors

Youden’s J

Cut-off value

Sensitivity

Specificity

PPV

NPV

DOR

TNFa

0,72

≥18,000

0,81

0,91

0,85

0,89

43

RHIa

0,23

≥9

0,71

0,52

0,48

0,74

3

Combined TNF RHI

0,57

≥18,000 and ≥ 9

0,57

1

1

0,79

∞

UCDAI

0,4

≥9

0,79

0,61

0,54

0,83

6

Mayo subscore

0,45

3

0,72

0,73

0,62

0,81

7

Calprotectin

0,51

≥2000

0,6

0,91

0,86

0,72

15

  1. Diagnostic odds ratio PPV: Positive predictive value NPV Negative predictive value
  2. a copies/μg mRNA bRobarts histopathology index score
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BMC Gastroenterology

ISSN: 1471-230X

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