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Table 3 Comparison of predictive value of RNTIC, MELD, MELD-Na and CTP in derivation cohort and validation cohort

From: A novel predictive model based on inflammatory markers to assess the prognosis of patients with HBV-related acute-on-chronic liver failure: a retrospective cohort study

Variables AUC
(95%)
Z Statistic P Value Cut-off Value Sensitivity
(%)
Specificity
(%)
PPV
(%)
NPV
(%)
Overall
Accuracy
(%)
Youden
Index
Derivation cohort
 RNTIC 0.873
(0.837–0.903)
   3.08 77.89 86.04 82.89 81.2 81.95 0.64
 MELD 0.732
(0.687–0.774)
8.227 <0.001 24.14 70.35 70.72 68.29 72.69 70.54 0.41
 MELD-Na 0.714
(0.668–0.757)
6.868 <0.001 18.00 84.4 50.50 60.21 78.17 66.27 0.35
 CTP 0.703
(0.657–0.747)
6.424 <0.001 10.00 82.91 47.30 58.51 75.54 64.13 0.30
Validation cohort
 RNTIC 0.845
(0.778–0.898)
   2.59 85.07 71.00 76.25 80.26 78.21 0.62
 MELD 0.768
(0.694–0.832)
2.867 0.004 22.24 69.64 83.00 68.42 82.83 77.56 0.53
 MELD-Na 0.759
(0.684–0.824)
2.952 0.003 19.12 73.21 71.00 70.83 70.24 70.51 0.44
 CTP 0.718
(0.641–0.787)
2.903 0.003 10.00 75.00 63.00 65.82 68.83 67.31 0.38
  1. Z Statistic: compared with AUC of RNTIC, P value: compared with AUC of RNTIC, RNTIC = 0.053 × RDW + 0.027 × NLR + 0.003 × TBIL+ 0.317 × INR + 0.003 × Cr, MELD model for end-stage liver disease, CTP child-Turcotte Pugh score, MELD-Na MELD-sodium score, NLR neutrophil/lymphocyte ratio, RDW red blood cell distribution width, TBIL total bilirubin, Cr creatinine, INR international normalized ratio, HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, NPV negative predictive value, PPV positive predict value