A novel predictive model based on inflammatory markers to assess the prognosis of patients with HBV-related acute-on-chronic liver failure: a retrospective cohort study

Table 3 Comparison of predictive value of RNTIC, MELD, MELD-Na and CTP in derivation cohort and validation cohort

Variables	AUC (95%)	Z Statistic	P Value	Cut-off Value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Overall Accuracy (%)	Youden Index
Derivation cohort
RNTIC	0.873 (0.837–0.903)			3.08	77.89	86.04	82.89	81.2	81.95	0.64
MELD	0.732 (0.687–0.774)	8.227	<0.001	24.14	70.35	70.72	68.29	72.69	70.54	0.41
MELD-Na	0.714 (0.668–0.757)	6.868	<0.001	18.00	84.4	50.50	60.21	78.17	66.27	0.35
CTP	0.703 (0.657–0.747)	6.424	<0.001	10.00	82.91	47.30	58.51	75.54	64.13	0.30
Validation cohort
RNTIC	0.845 (0.778–0.898)			2.59	85.07	71.00	76.25	80.26	78.21	0.62
MELD	0.768 (0.694–0.832)	2.867	0.004	22.24	69.64	83.00	68.42	82.83	77.56	0.53
MELD-Na	0.759 (0.684–0.824)	2.952	0.003	19.12	73.21	71.00	70.83	70.24	70.51	0.44
CTP	0.718 (0.641–0.787)	2.903	0.003	10.00	75.00	63.00	65.82	68.83	67.31	0.38

Z Statistic: compared with AUC of RNTIC, P value: compared with AUC of RNTIC, RNTIC = 0.053 × RDW + 0.027 × NLR + 0.003 × TBIL+ 0.317 × INR + 0.003 × Cr, MELD model for end-stage liver disease, CTP child-Turcotte Pugh score, MELD-Na MELD-sodium score, NLR neutrophil/lymphocyte ratio, RDW red blood cell distribution width, TBIL total bilirubin, Cr creatinine, INR international normalized ratio, HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, NPV negative predictive value, PPV positive predict value

ISSN: 1471-230X