Table 7 Laboratory findings and blood coagulation tests of subjects with ACLF stratified by bleeding events. Median (IQR) is shown with p-values for the group differences based on Mann-Whitney U test
Limits of normal | No bleeding n = 13 | % outside the limitsof normal | Bleeding n = 9 | % outside the limitsof normal | p-value* | |
|---|---|---|---|---|---|---|
Laboratory findings | ||||||
Hemoglobin | 13–17 g/dl | 9.2 (2.05) | 92.3% | 9.0 (3.2) | 100% | 0.55 |
Creatinine | 0.6–1.2 mg/dl | 2.39 (2.4) | 84.6% | 1.6 (2.5) | 77.8% | 0.47 |
Bilirubin | < 1.0 mg/dl | 3.1 (20.6) | 76.9% | 4.1 (9.7) | 100% | 0.43 |
AST | < 46 U/l | 62.0 (44.0) | 61.5% | 42.5 (9.7) | 22.2% | 0.36 |
ALT | < 50 U/l | 27.0 (42.0) | 18.2% | 27.0 (65.5) | 14.3% | 0.44 |
GGT | < 60 U/l | 92.0 (119.0) | 69.2% | 71.0 (144.0) | 55.6% | 0.29 |
Alkaline Phosphatase | 40–130 U/l | 106.0 (111.0) | 36.4% | 97.5 (70.3) | 11.1% | 1.0 |
Albumin | 30–50 g/l | 31.0 (7.55) | 36.4% | 30.2 (6.03) | 57.1% | 0.64 |
Coagulation tests | ||||||
INR | < 1.2 | 1.7 (0.9) | 84.6% | 1.4 (0.6) | 77.8% | 0.64 |
PT | 70–120% | 40.0 (30) | 100% | 0.51 (0.2) | 44.4% | 0.70 |
aPTT | < 36 s | 32.9 (15.4) | 30.8% | 30.2 (27.6) | 22.2% | 0.85 |
Platelet count | 150–440/nl | 72.5 (75.3) | 23.1% | 57.0 (40.5) | 44.4% | 0.32 |
Fibrinogen | 1.8–3.5 g/l | 1.9 (1.6) | 38.5% | 1.5 (0.8) | 77.8% | 0.05 |
Antithrombin III-activity | 80–120% | 45.7 (41.0) | 92.3% | 39.7 (28.0) | 100% | 0.47 |
Thrombin time | < 22 s | 20.2 (3.2) | 15.4% | 20.5 (8.9) | 44.4% | 0.16 |
Protein C | 60–120% | 32.3 (43.0) | 76.9% | 36.4 (27.0) | 77.8% | 0.74 |
Protein S (free) | >80% | 51.8 (42.0) | 76.9% | 57.4 (27.0) | 88.9% | 1.0 |
Factor V | 70–120% | 46.0 (37.0) | 92.3% | 37.0 (26.0) | 88.9% | 0.51 |
Factor VIII | 80–120% | 255.5 (244.0) | 100% | 209.7 (116.0) | 88.9% | 0.96 |
von-Willebrand antigen | 70–120% | 456.9 (210.0) | 100% | 353.6 (337.0) | 100% | 0.23 |
ADAMTS13 activity | 40–130% | 81.9 (27.0) | 0.0% | 74.3 (57.0) | 22.2% | 0.34 |