Table 2 Laboratory findings and blood coagulation tests of study population. Median (IQR) is shown with p-values for the group differences based on Mann-Whitney U test
Limits of normal | Non-ACLF n = 55 | % outside the limits of normal | ACLF n = 22 | % outside the limits of normal | p-value | |
|---|---|---|---|---|---|---|
Laboratory findings | ||||||
Hemoglobin | 13–17 g/dl | 12.0 (4.1) | 65.5% | 8.6 (2.1) | 95.5% | < 0.0001 |
Creatinine | 0.6–1.2 mg/dl | 0.9 (0.5) | 18.2% | 2.18 (1.6) | 77.3% | < 0.0001 |
Bilirubin | < 1.0 mg/dl | 1.3 (1.5) | 63.6% | 3.9 (8.9) | 81.8% | < 0.0001 |
AST | < 46 U/l | 46.5 (35.3) | 47.3% | 58.0 (53.0) | 45.5% | 0.78 |
ALT | < 50 U/l | 30.5 (34.3) | 24.1% | 26.0 (31.0) | 22.2% | 0.60 |
GGT | < 60 U/l | 94.0 (137.0) | 67.3% | 81.0 (103.5) | 63.6% | 0.30 |
Alkaline phosphatase | 40–130 U/l | 138.5 (110.3) | 48.1% | 106.0 (97.0) | 27.8% | 0.06 |
Albumin | 30–50 g/l | 36.2 (8.4) | 17.3% | 31.0 (5.7) | 44.4% | < 0.0001 |
Coagulation tests | ||||||
INR | < 1.2 | 1.2 (0.2) | 32.7% | 1.4 (0.8) | 81.8% | < 0.0001 |
PT (Quick) | 70–120% | 70.0 (20.0) | 60.0% | 50.0 (30.0) | 54.5% | < 0.0001 |
aPTT | < 36 s | 26.6 (4.7) | 1.9% | 31.8 (16.1) | 31.8% | < 0.0001 |
Platelet count | 150–440/nl | 112.0 (85.0) | 7.3% | 57.0 (71.3) | 31.8% | 0.002 |
Fibrinogen | 1.8–3.5 g/l | 2.7 (1.4) | 14.5% | 1.6 (1.2) | 59.1% | 0.001 |
Antithrombin III-activity | 80–120% | 71.0 (32.0) | 67.3% | 42.1 (33.0) | 95.5% | < 0.0001 |
Thrombin time | < 22 s | 18.6 (1.9) | 1.8% | 20.5 (5.45) | 27.3% | 0.02 |
Protein C | 60–120% | 51.5 (36.0) | 67.3% | 36.4 (31.0) | 77.3% | 0.004 |
Protein S (free) | > 80% | 69.4 (24.0) | 65.5% | 52.9 (33.0) | 81.8% | 0.007 |
Factor V | 70–120% | 69.2 (44.0) | 49.1%* | 41.7 (30.0) | 90.9% | < 0.0001 |
Factor VIII | 80–120% | 242.2 (81.1) | 100% | 249.3 (128.0) | 95.5% | 0.98 |
von-Willebrand antigen | 70–120% | 294.8 (262.0) | 100% | 411.0 (259.0) | 100% | 0.003 |
ADAMTS13 activity | 40–130% | 100.0 (15.0) | 2.0% | 81.0 (38.0) | 9.5% | 0.004 |