Standard-dose groupb (n = 35) | High-dose groupc (n = 38) | P-value | |||||||
---|---|---|---|---|---|---|---|---|---|
n | Baseline | 4 week (△) | 8 week (△) | n | Baseline | 4 week (△) | 8 week (△) | ||
Total symptoms | 35 | 4.46 ± 2.76 | 2.09 ± 1.96 (−2.37 ± 1.70) | 1.83 ± 1.79 (− 2.63 ± 1.78) | 38 | 4.76 ± 2.01 | 0.92 ± 1.42 (−3.84 ± 1.98) | 0.89 ± 1.37 (−3.87 ± 1.85) | < 0.001 |
Typical symptomsd | 25 | 2.56 ± 1.12 | 1.16 ± 1.34 (− 1.40 ± 1.26) | 0.80 ± 0.91 (− 1.76 ± 0.83) | 29 | 2.69 ± 1.00 | 0.28 ± 0.60 (− 2.41 ± 1.24) | 0.24 ± 0.44 (− 2.45 ± 1.09) | 0.004 |
Heartburn | 21 | 2.14 ± 0.73 | 0.90 ± 1.04 (− 1.24 ± 0.83) | 0.76 ± 0.89 (− 1.38 ± 0.74) | 19 | 2.26 ± 0.56 | 0.26 ± 0.65 (− 2.00 ± 0.82) | 0.21 ± 0.42 (− 2.05 ± 0.71) | 0.004 |
Acid regurgitation | 11 | 1.73 ± 0.65 | 0.36 ± 0.51 (− 1.36 ± 0.51) | 0.36 ± 0.51 (− 1.36 ± 0.51) | 16 | 2.19 ± 0.54 | 0.19 ± 0.40 (− 2.00 ± 0.63) | 0.19 ± 0.40 (− 2.00 ± 0.52) | 0.005 |
Atypical symptomse | 27 | 3.41 ± 1.93 | 1.85 ± 1.51 (− 1.56 ± 1.19) | 1.56 ± 1.28 (− 1.85 ± 1.35) | 34 | 3.03 ± 1.14 | 0.79 ± 1.23 (− 2.24 ± 1.28) | 0.79 ± 1.27 (− 2.24 ± 1.26) | 0.079 |
Chest pain | 7 | 2.29 ± 0.49 | 1.14 ± 0.90 (− 1.14 ± 0.90) | 0.71 ± 0.76 (− 1.57 ± 0.54) | 11 | 2.27 ± 0.65 | 0.91 ± 0.94 (− 1.36 ± 0.92) | 0.82 ± 1.08 (− 1.45 ± 0.93) | 0.692 |
Cough | 6 | 2.17 ± 0.75 | 1.50 ± 1.23 (− 0.67 ± 0.82) | 1.33 ± 1.03 (− 0.83 ± 0.75) | 8 | 2.25 ± 0.71 | 0.38 ± 0.74 (− 1.87 ± 1.13) | 0.38 ± 0.52 (− 1.87 ± 1.13) | 0.044 |
Globus | 20 | 2.30 ± 0.66 | 1.35 ± 0.75 (− 0.95 ± 0.61) | 1.20 ± 0.77 (− 1.10 ± 0.72) | 17 | 2.47 ± 0.51 | 0.47 ± 0.80 (− 2.00 ± 0.79) | 0.53 ± 0.80 (− 1.94 ± 0.75) | < 0.001 |
Wheezing | 1 | 2.00 ± 0.00 | 1.00 (− 1.00) | 1.00 (− 1.00) | 0 | – | – | – | – |
Laryngopharyngitis | 0 | – | – | – | 0 | – | – | – | – |
Hoarseness | 2 | 2.00 ± 0.00 | 0.50 ± 0.71 (−1.50 ± 0.71) | 0.50 ± 0.71 (− 1.50 ± 0.71) | 4 | 3.00 ± 0.00 | 1.50 ± 1.29 (− 1.50 ± 1.29) | 1.50 ± 1.29 (− 1.50 ± 1.29) | 1.000 |
Belching | 5 | 2.20 ± 0.45 | 0.80 ± 1.01 (− 1.40 ± 0.89) | 0.60 ± 0.89 (− 1.60 ± 0.55) | 3 | 1.33 ± 0.58 | 0.00 ± 0.00 (− 1.33 ± 0.58) | 0.00 ± 0.00 (− 1.33 ± 0.58) | 0.822 |
Dysphagia | 0 | – | – | – | 1 | 2.00 ± 0.00 | 0.00 (− 2.00) | 0.00 (− 2.00) | – |