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Table 2 Comparison of composite NAFLD Activity Score (NAS) in human NASH patients and GAN DIO-NASH mice

From: Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

   NAS
Group n 0 1 2 3 4 5 6 7 8
Human subjects Healthy normal-weight 14 13 1
NASH 16 12 4
C57BL/6 J mice Chow-fed lean mice 10 10
GAN DIO-NASH mice 25 6 7 11 1
  1. Composite NAFLD Activity Score (NAS) in liver biopsy samples from normal controls, human NASH patients and GAN DIO-NASH mice. Histopathology was scored according to the criteria outlined by the NASH-Clinical Research Network [27]