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Table 1 Characteristics of studies included in the meta-analysis

From: The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis

author year region specimen conference test index test study design markers studied normalization controls Low AFP HCC patients non-HCC controls QUADAS score reference
No. population No. population
Jian Zhou 2011 China plasma histology RT-PCR cohort 122, 223, 26a, 27a, 192, 21, 801 miR-1228 139 HBV-HCC (139) 187 HC (66) CHB (68)HBV-LC (53) 10 18
Angela M Liu 2012 China serum histology RT-PCR cohort 15b, 130b, 21, 183 n.a. 30 HBV-HCC (30) 59 HC (30) CHB (29) 11 19
Duo Zuo 2015 China serum histology RT-PCR case-control 125b, 223, 27a, 26a U6 38 HBV-HCC (38) 48 HC (27) CHB (21) 11 20
Xuejia Lin 2015 China serum histology or imaging RT-PCR cohort 29a, 29c, 133a, 143, 145, 192, 505 cel-miR-67 119 HBV-HCC (119) 438 HC (159) CHB (119) HBV-LC (118) HBV (42) 8 21
Chao-Hung Hung 2016 China serum histology RT-PCR case-control 122, 7b U6 92 HBV-HCC (92) 30 HBV-DN (30) 8 22
Amit Ghosh 2016 India plasma histology or imaging RT-PCR case-control 126, 142-3p cel-miR-39 18 HBV-HCC (18) 38 HBV-LC (20) CHB (18) 6 23
Shanshan Chen 2016 China plasma histology or imaging RT-PCR case-control 125b U6 31 HBV-HCC (31) 158 HC (56) CHB (50) HBV-LC (52) 8 24
Shanshan Chen 2016 China plasma histology RT-PCR case-control 205 U6 32 HBV-HCC (32) 49 HBV-LC (49) 8 25
  1. CHB chronic hepatitis B, HC healthy control, LC liver cirrhosis, n.a. not available, HBV hepatitis B virus infection, HCC hepatocellular carcinoma, HBV-HCC hepatitis B virus-associated HCC, DN dysplastic nodule