Table 1 Characteristics of studies included in the meta-analysis
author | year | region | specimen | conference test | index test | study design | markers studied | normalization controls | Low AFP HCC patients | non-HCC controls | QUADAS score | reference | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | population | No. | population | |||||||||||
Jian Zhou | 2011 | China | plasma | histology | RT-PCR | cohort | 122, 223, 26a, 27a, 192, 21, 801 | miR-1228 | 139 | HBV-HCC (139) | 187 | HC (66) CHB (68)HBV-LC (53) | 10 | 18 |
Angela M Liu | 2012 | China | serum | histology | RT-PCR | cohort | 15b, 130b, 21, 183 | n.a. | 30 | HBV-HCC (30) | 59 | HC (30) CHB (29) | 11 | 19 |
Duo Zuo | 2015 | China | serum | histology | RT-PCR | case-control | 125b, 223, 27a, 26a | U6 | 38 | HBV-HCC (38) | 48 | HC (27) CHB (21) | 11 | 20 |
Xuejia Lin | 2015 | China | serum | histology or imaging | RT-PCR | cohort | 29a, 29c, 133a, 143, 145, 192, 505 | cel-miR-67 | 119 | HBV-HCC (119) | 438 | HC (159) CHB (119) HBV-LC (118) HBV (42) | 8 | 21 |
Chao-Hung Hung | 2016 | China | serum | histology | RT-PCR | case-control | 122, 7b | U6 | 92 | HBV-HCC (92) | 30 | HBV-DN (30) | 8 | 22 |
Amit Ghosh | 2016 | India | plasma | histology or imaging | RT-PCR | case-control | 126, 142-3p | cel-miR-39 | 18 | HBV-HCC (18) | 38 | HBV-LC (20) CHB (18) | 6 | 23 |
Shanshan Chen | 2016 | China | plasma | histology or imaging | RT-PCR | case-control | 125b | U6 | 31 | HBV-HCC (31) | 158 | HC (56) CHB (50) HBV-LC (52) | 8 | 24 |
Shanshan Chen | 2016 | China | plasma | histology | RT-PCR | case-control | 205 | U6 | 32 | HBV-HCC (32) | 49 | HBV-LC (49) | 8 | 25 |