BMC Gastroenterology

Table 2 Phospho- and sphingolipids (ng/μl) of study population. Serum samples were quantified in ng/μl serum. Mean ± SD or median (IQR) are shown with p-values for the group differences based on Welch’s t-test (a) or Mann-Whitney U test (b)

From: Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis

		Healthy n = 20	HH n = 53	p-value
*Phospholipids*
PC	Saturated	996.2 ± 369.3	750.6 ± 30.6	< 0.0008^a
	MUFA	2327.0 ± 866.7	2401.8 ± 976.2	0.75^a
	PUFA	6163.9 ± 2104.8	8001.3 ± 2334.6	0.003^a
	Alkyl	521.6 ± 169.7	619.3 ± 203.1	0.045^a
	Total	10,008.8 ± 3154.7	11,773.0 ± 3339.3	0.04^a
LPC	Saturated	51.5 ± 11.3	56.9 ± 14.6	0.10^a
	MUFA	12.5 ± 3.4	10.5 ± 2.7	0.02^a
	PUFA	19.6 ± 4.2	16.2 ± 4.2	0.004^a
	Total	83.7 ± 17.6	83.6 ± 19.7	0.98^a
PI	MUFA	14.4 ± 6.5	19.7 ± 10.0	0.01^a
	PUFA	137.4 ± 50.1	165.0 ± 61.0	0.06^a
	Total	152.1 ± 55.7	184.7 ± 69.1	0.04^a
PS	MUFA	0.4 (2.6)	0.0 (4.0)	0.71^b
	PUFA	17.7 (17.9)	24.6 (52.0)	0.15^b
	Total	18.4 (18.3)	26.5 (59.5)	0.18^b
PE	MUFA	75.2 (55.4)	91.9 (329.7)	0.05^b
	PUFA	198.6 (103.5)	289.2 (257.0)	0.005^b
	Total	276.4 (123.2)	407.8 (573.2)	0.008^b
LPE	Saturated	1.2 (0.9)	1.3 (0.8)	0.87^b
	MUFA	0.5 (0.4)	0.5 (0.9)	0.95^b
	PUFA	1.6 (0.8)	2.3 (3.0)	0.045^b
	Total	3.6 (1.7)	4.5 (4.8)	0.10^b
*Sphingolipids*
SM	Saturated	711.3 ± 271.3	876.1 ± 279.5	0.03^a
	MUFA	2168.3 ± 1339.6	2879.7 ± 1173.2	0.045^a
	PUFA	1537.9 ± 517.6	1728.4 ± 380.7	0.15^a
	Alkyl	344.3 ± 256.5	465.4 ± 236.7	0.08^a
	Total	4761.8 ± 2104.7	5949.6 ± 1743.3	0.03^a
Ratio PC/PE		34.7	22.2

HH hereditary hemochromatosis; IQR interquartile range; LPC lysophosphatidylcholine; LPE lysophosphatidylethanoletamine; MUFA monounsaturated fatty acid; PC phosphatidylcholine; PE phosphatidylethanolamine; PS phosphatidylserine; PUFA polyunsaturated fatty acid; SD standard deviation; SM sphingomyelin;

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ISSN: 1471-230X

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