Table 1 Baseline characteristics of the HBV-ACLF, CHB group and health control groups

Patients, no.

9

25

27

Age, y (median, range)

37 (29–50)

31 (15–55)

42 (24–59)

0.1182

Gender, M/F

5/4

16/9

23/4

0.1510

ALT (IU/L) (median, range)

19 (15–38)

25 (13–106)

230 (17–2175)

<  0.0001

Bilirubin (μmol/L) (median, range)

10.5 (8.3–23.3)

12.2 (5.2–27.8)

314.9 (20–830.1)

<  0.0001

Albumin (g/L) (median, range)

ND

46 (33–49)

32 (27–42)

<  0.0001*

Creatinine (μmol/L) (median, range)

78 (47–93)

73 (36–80)

67 (21–646)

0.8256

INR

ND

1.03 (0.90–1.10)

1.90 (1.07–4.93)

<  0.0001*

AFP (ng/ml) (median, range)

ND

2.02 (1.07–348.2)

59.98 (3.85–959.8)

< 0.0001*

HBeAg positive, n(%)

0

13 (52%)

17 (63%)

0.9506*

HBV DNA (log₁₀ IU/ml) (median, range)

ND

7.453 (2.699–8.656)

4.189 (2.699–7.477)

0.0178*

MELDs (median, range)

ND

2 (2–6)

23 (10–43)

0.0005*

CLIF-C OFs (median, range)

ND

6 (6–6)

8 (6–12)

Cannot be calculated