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Table 2 Test characteristics of two biomarker levels to predict endoscopic remission

From: Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis

 

eMayo

UCEIS score

PGE-MUM

FIT

PGE-MUM

FIT

Cut-off value

30.9 μg/g∙Cr

742 ng/mL

20.8 μg/g•Cr

31 ng/mL

AUC

0.644

0.826

0.636

0.789

95%CI

0.523–0.765

0.74–0.912

0.522–0.75

0.698–0.879

PPV

55.2%

81.2%

60.3%

70.2%

NPV

73.0%

75.0%

67.6%

82.9%

Sensitivity

48.5%

63.6%

76.1%

87.0%

Specificity

78.0%

88.1%

50.0%

63.0%

Accuracy

67.4%

79.3%

63.0%

75.0%

  1. eMayo Mayo endoscopic subscore, UCEIS Ulcerative Colitis Endoscopic Index of Severity, PGE-MUM Prostaglandin E-Major Urinary Metabolite, FIT fecal immunochemical occult blood test, AUC area under curve, CI confidence interval, PPV Positive-predictive value, NPV negative-predictive value