Table 3 Association between 5 SNPs and risk of H. pylori infection under different genetic models
From: Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer
Locus | Model | Genotype | Control [n(%)] | Case [n(%)] | OR (95%CI)a | P | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
LATS1 rs9393175 | codominant | G/G | 125 (55.56) | 128 (64.00) | 1 | – | 1092.330 | 1115.760 |
A/G | 88 (39.11) | 61 (30.50) | 0.671 (0.443–1.010) | 0.057 | ||||
A/A | 12 (5.33) | 11 (5.50) | 0.916 (0.383–2.175) | 0.842 | ||||
dominant | G/G | 125 (55.56) | 128 (64.00) | 1 | – | 591.691 | 607.899 | |
A/A + A/G | 100 (44.44) | 72 (36.00) | 0.700 (0.472–1.035) | 0.074 | ||||
recessive | G/G + A/G | 213 (94.67) | 189 (94.50) | 1 | – | 594.873 | 611.081 | |
A/A | 12 (5.33) | 11 (5.50) | 1.062 (0.449–2.487) | 0.889 | ||||
overdominant | G/G + A/A | 137 (60.89) | 139 (69.50) | – | 591.254 | 607.462 | ||
A/G | 88 (39.11) | 61 (30.50) | 0.675 (0.449–1.011) | 0.058 | ||||
log-additive | – | – | – | 0.792 (0.570–1.093) | 0.158 | 592.876 | 609.084 | |
LATS2 rs558614 | codominant | T/T | 63 (29.30) | 60 (30.46) | 1 | – | 579.405 | 599.511 |
C/T | 106 (49.30) | 91 (46.19) | 0.900 (0.572–1.416) | 0.648 | ||||
C/C | 46 (21.40) | 46 (23.35) | 1.042 (0.606–1.794) | 0.881 | ||||
dominant | T/T | 63 (29.30) | 60 (30.46) | 1 | – | 577.742 | 593.826 | |
C/C + C/T | 152 (70.70) | 137 (69.54) | 0.943 (0.617–1.442) | 0.787 | ||||
recessive | T/T + C/T | 169 (78.60) | 151 (76.65) | 1 | – | 577.614 | 593.698 | |
C/C | 46 (21.40) | 46 (23.35) | 1.112 (0.698–1.772) | 0.654 | ||||
overdominant | T/T + C/C | 109 (50.70) | 106 (53.81) | 1 | – | 577.428 | 593.512 | |
C/T | 106 (49.30) | 91 (46.19) | 0.884 (0.599–1.303) | 0.534 | ||||
log-additive | – | – | – | 1.012 (0.773–1.326) | 0.930 | 577.807 | 593.891 | |
LATS2 rs9552315 | codominant | T/T | 45 (20.18) | 60 (30.00) | 1 | – | 588.160 | 608.397 |
C/T | 119 (53.36) | 88 (44.00) | 0.549 (0.339–0.881) | 0.014 | ||||
C/C | 59 (26.46) | 52 (26.00) | 0.650 (0.377–1.114) | 0.118 | ||||
dominant | T/T | 45 (20.18) | 60 (30.00) | 1 | – | 586.672 | 602.862 | |
C/C + C/T | 178 (79.82) | 140 (70.00) | 0.582 (0.370–0.909) | 0.018 | ||||
recessive | T/T + C/T | 164 (73.54) | 148 (74.00) | 1 | – | 592.331 | 608.521 | |
C/C | 59 (26.46) | 52 (26.00) | 0.970 (0.626–1.499) | 0.891 | ||||
overdominant | T/T + C/C | 104 (46.64) | 112 (56.00) | 1 | – | 588.616 | 604.805 | |
C/T | 119 (53.36) | 88 (44.00) | 0.685 (0.466–1.005) | 0.054 | ||||
log-additive | – | – | – | 0.811 (0.618–1.061) | 0.128 | 590.018 | 606.207 | |
LATS2 rs7317471 | codominant | C/C | 177 (80.09) | 173 (85.64) | 1 | – | 590.953 | 611.190 |
C/T | 39 (17.65) | 28 (13.86) | 0.746 (0.435–1.266) | 0.281 | ||||
T/T | 5 (2.26) | 1 (0.50) | 0.206 (0.011–1.230) | 0.152 | ||||
dominant | C/C | 177 (80.09) | 173 (85.64) | 1 | – | 590.590 | 606.780 | |
C/T + T/T | 44 (19.91) | 29 (14.36) | 0.684 (0.405–1.143) | 0.151 | ||||
recessive | C/C + C/T | 216 (97.74) | 201 (99.50) | 1 | – | 590.126 | 606.316 | |
T/T | 5 (2.26) | 1 (0.50) | 0.217 (0.011–1.362) | 0.165 | ||||
overdominant | C/C + T/T | 182 (82.35) | 174 (86.14) | 1 | – | 591.689 | 607.879 | |
C/T | 39 (17.65) | 28 (13.86) | 0.764 (0.446–1.295) | 0.320 | ||||
log-additive | – | – | – | 0.667 (0.413–1.057) | 0.090 | 589.722 | 609.912 | |
LATS2 rs9509492 | codominant | A/A | 87 (39.01) | 74 (36.82) | 1 | – | 595.106 | 615.355 |
A/G | 98 (43.95) | 96 (47.76) | 1.147 (0.754–1.746) | 0.522 | ||||
G/G | 38 (17.04) | 31 (15.42) | 0.964 (0.544–1.699) | 0.898 | ||||
dominant | A/A | 87 (39.01) | 74 (36.82) | 1 | – | 593.488 | 609.687 | |
A/G + G/G | 136 (60.99) | 127 (63.18) | 1.096 (0.739–1.627) | 0.649 | ||||
recessive | A/A + A/G | 185 (82.96) | 170 (84.58) | 1 | – | 593.516 | 609.715 | |
G/G | 38 (17.04) | 31 (15.42) | 0.894 (0.529–1.500) | 0.672 | ||||
overdominant | A/A + G/G | 125 (56.05) | 105 (52.24) | 1 | – | 593.123 | 609.322 | |
A/G | 98 (43.95) | 96 (47.76) | 1.160 (0.790–1.702) | 0.449 | ||||
log-additive | – | – | – | 1.013 (0.772–1.329) | 0.927 | 593.687 | 609.886 |