Table 7 Delayed diarrheacompared withUGT1A1wild-type、single-point and double-point mutants (%)
Genotype | Total n | Delayed diarrhea n(%) | X2 | P | |
|---|---|---|---|---|---|
UGT1A1*28 | 0~II | III~IV | 6.308 | 0.017 | |
6/6 | 60 | 53 (88.3) | 7 (11.7) | ||
6/7 | 26 | 17 (65.4) | 9 (34.6) | ||
UGT1A1*6 | 13.745 | 0.001 | |||
G/G | 66 | 60 (90.9) | 6 (10.0) | ||
G/A + A/A | 20 | 11(55.0) | 9 (24.3) | ||
Numbers of mutational alleles | 8.802 | 0.005 | |||
Double single type | 53 | 50 (94.3) | 3 (5.7) | ||
Single variant | 22 | 17(77.3) | 5 (22.7) | ||
Double variant | 11 | 7 (63.6) | 4 (36.3) | ||