Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang

Table 11 Correlation between UGT1A1 genetic polymorphisms and irinotecan dose reduction in patients with CRC

Irinotecan dose reduction	UGT1A1*28		P	UGT1A1*6		P
Irinotecan dose reduction	TA6/6 Number (%)	TA6/7 + TA7/7 Number (%)	P	G/G Number (%)	G/A Number (%)	P
Yes	6 (10.0)	9 (45.0)	0.014	7 (10.6)	8 (40.0)	0.007
No	54 (90.0)	11 (55.0)	0.014	59 (89.4)	12 (60.0)	0.007

ISSN: 1471-230X