Table 10 Response compared withUGT1A1wild-type、single-point and double-point mutants (%)
Genotype | Total n | ORR % (n) | X2 | P | DCR % (n) | X2 | P |
|---|---|---|---|---|---|---|---|
UGT1A1*28 | 0.120 | 0.812 | 0.123 | 0.794 | |||
6/6 | 60 | 38.3 (23) | 73.3 (44) | ||||
6/7 | 26 | 42.3 (11) | 76.9 (20) | ||||
UGT1A1*6 | 0.106 | 0.799 | 0.005 | 1.000 | |||
G/G | 66 | 40.9 (27) | 74.2 (49) | ||||
G/A + A/A | 20 | 45.0 (9) | 75.0 (15) | ||||
Numbers of mutational alleles | 0.069 | 1.000 | 0.329 | 0.879 | |||
Double single type | 53 | 41.5 (22) | 75.5 (40) | ||||
Single variant | 22 | 40.9(9) | 72.7 (16) | ||||
Double variant | 11 | 44.5 (5) | 81.8 (9) |