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Table 2 Univariate and multivariate Cox regression analyses of liver-related mortality

From: “Sarcopenia and intramuscular fat deposition are associated with poor survival in Indonesian patients with hepatocellular carcinoma: a retrospective study”

VariableNo. at riskaNo. of events3-month survival, % ± SDUnivariate Cox regression analysisMultivariate Cox regression analysis
HR95% CIP-valueHR95% CIP-value
Age
  < 55 years old473357 ± 71.000(reference)    
  ≥ 55 years old534445 ± 71.2690.802–2.0070.307   
Gender
 Male§746046 ± 61.8451.066–3.1940.0293.2111.709–6.034< 0.001
 Female261765 ± 91.000(reference) 1.000(reference) 
Body mass index
 Underweight312448 ± 91.1080.658–1.8650.700   
 Normal weight443550 ± 81.000(reference)    
 Overweight251855 ± 100.7960.468–1.4680.519   
Sarcopenia
 No694962 ± 61.000(reference) 1.000(reference) 
 Yesc312826 ± 82.9501.836–4.740<.0.0011.9211.129–3.2680.016
IMF deposition
 No351789 ± 51.000(reference) 1.000(reference) 
 Yesc656031 ± 65.4873.106–9.693<.0.0013.5801.895–6.764< 0.001
Visceral adiposity
 No715548 ± 61.000(reference)    
 Yes292259 ± 60.8900.542–1.4610.644   
Viral status
 HBV585140 ± 62.3261.380–3.9200.0021.2230.708–2.1140.471
 HCV8650 ± 181.3380.536–3.3400.533   
 None342071 ± 81.000(reference) 1.000(reference) 
Child-Pugh class
 A604268 ± 61.000(reference) 1.000(reference) 
 B322728 ± 82.1291.306–3.4690.0020.4060.087–1.9010.252
 C8813 ± 125.0692.342–10.973<.0.0010.5780.110–3.0310.516
TNM-AJCC stage AJCC - 8th Edition
 TNM-AJCC 1201385 ± 81.000(reference) 1.000(reference) 
 TNM-AJCC 25560 ± 223.5861.244–10.3390.0181.3040.439–3.8750.633
 TNM-AJCC 3322156 ± 91.6180.797–3.2860.183   
 TNM-AJCC 4433830 ± 73.6631.908–7.031<.0.0011.1770.341–4.0630.796
TNM-LCSGJ stage
 TNM-LCSSGJ 2211486 ± 81.000(reference) 1.000(reference) 
 TNM-LCSSGJ 3322253 ± 91.6870.850–3.3470.135   
 TNM-LCSSGJ 4474134 ± 73.3081.763–6.206<.0.0010.8350.453–1.5420.565
JIS score
 JIS score 1181289 ± 71.000(reference) 1.000(reference) 
 JIS score 2231561 ± 101.4260.737–4.4940.362   
 JIS score 3312354 ± 92.1280.818–4.4090.0381.6420.679–3.9740.271
 JIS score 4c232217 ± 84.8022.053–6.205< 0.0012.0671.119–3.8170.020
 JIS score 5550 ± 028.3738.802–91.456<.0.0013.8430.938–15.7350.061
BCLC stage
 A72100 ± 01.000(reference) 1.000(reference) 
 B251388 ± 73.8170.829–17.5840.086   
 C§595337 ± 612.4192.907–53.0670.0012.3961.248–4.6000.009
 D§990 ± 065.95812.94–336.25< 0.0016.1311.835–20.4780.003
AFP level
  < 200 ng/ml483362 ± 71.000(reference) 1.000(reference) 
  ≥ 200 ng/ml524440 ± 71.9161.210–3.0340.0061.0630.636–1.7770.815
  1. HR Hazard ratio, CI Confidence interval, IMF Intramuscular fat, HCV Hepatitis C virus, HBV Hepatitis B virus, BCLC Barcelona Clinic Liver Cancer, TNM Tumour–node–metastasis, AJCC American Joint Committee of on Cancer, LCSGJ Liver Cancer Study Group of Japan, JIS Japan Integrated Staging; AFP Alpha-fetoprotein. aEqual to the total number of patients (N = 100). bNumber of deaths during the 3-month observation period. cVariables that independently predicted the HCC outcome based on univariate and multivariate analyses