Table 2 Distribution of CD8+ T-cell subsets reflecting immunosenesence by liver fibrosis status among art-naïve PLWHA with recent heavy alcohol use
T-cell subsets as a proportion of CD8+ T-cells | Mean (SD) unless otherwise stated | p-value | ||
|---|---|---|---|---|
Overall | No advanced fibrosis/cirrhosis | Advanced fibrosis/cirrhosis | ||
CD8 + CD28-CD57+ | 35.6 (15.7) | 35.4 (15.5) | 36.1 (16.7) | 0.85 |
CD8+ memory | 34.4 (13.8) | 34.9 (13.7) | 32.3 (14.4) | 0.40 |
CD8+ naive | 38.7 (15.0) | 39.3 (14.0) | 36.4 (18.6) | 0.44 |
CD8 naïve:memory ratio median (25th, 75th) | 1.56 (0.99, 2.40) | 1.54 (0.95, 2.30) | 1.82 (1.17, 3.00) | 0.26 |