Effectiveness, benefit harm and cost effectiveness of colorectal cancer screening in Austria

BMC Gastroenterology

Table 2 Comparative population fact box for benefits and harms (per 1000 persons)

Outcome	10-yearly Colonoscopy	Annual FIT	Differences FIT vs. Colonoscopy
Life-years gained:	394	491	97
CRC-related deaths averted	30	35	5
CRC cases averted	61	69	8
Additional complications due to colonoscopy (hospital admissions)	1.2	1.2	0
Total positive test results	679	2206	1527

Numbers pertain to a cohort of 1000 persons 40 years of age who were followed until death in comparison to No Screening. Full adherence to screening strategies including follow-up and surveillance tests was assumed. CRC Colorectal cancer, FIT Fecal immunochemical test screening strategy. FIT: 40–75 years old average - risk men and women. Colonoscopy: 50–70 years old average - risk men and women, all screening strategies include index testing, further diagnostics (including colonoscopy), surveillance (colonoscopy), treatment and follow up interventions; annual guaiac-fecal occult blood test screening strategy is dominated by annual FIT in benefit - harm analysis and, therefore, not included in table.

ISSN: 1471-230X