Table 2 Preoperative predictors of irritable bowel syndrome (IBS)-like symptoms 2 years after Roux-en-Y-gastric bypass (RYGB)
Preoperative characteristics | Patients without IBS-like symptoms after RYGB n = 172 | Patients with IBS-like symptoms after RYGB n = 61 | Odds ratio (95% CI) | Statistics (p-values) | Adjusted for all significant predictors and center of inclusion | |
|---|---|---|---|---|---|---|
Odds ratio (95% CI) | Statistics (p-values) | |||||
Gender (female) | 127/172 (74%) | 50/61 (82%) | 1.6 (0.77–3.4) | 0.20 | ||
Age (years) | 43.3 (9.3) | 43.3 (8.4) | 1.0 (0.94–1.0) | 0.66 | ||
Body mass index (kg/m2) | 42.8 (4.9) | 43.1 (4.6) | 1.0 (0.96–1.1) | 0.65 | ||
Living with partner | 118/171 (69%) | 47/61 (77%) | 1.5 (0.77–3.0) | 0.24 | ||
Working full time | 105/171 (61%) | 28/61 (46%) | 0.53 (0.30–0.96) | 0.037 | ||
Smokers | 39/168 (23%) | 10/59 (17%) | 0.68 (0.31–1.5) | 0.32 | ||
Type 2 diabetes | 42/172 (24%) | 15/61 (25%) | 1.0 (0.51–2.0) | 0.98 | ||
Hypertension | 74/171 (43%) | 25/61 (40%) | 0.76 (0.50–1.7) | 0.76 | ||
Hypothyroidism | 14/172 (8%) | 8/61 (13%) | 1.7 (0.68–4.3) | 0.26 | ||
Fibromyalgia | 16/171 (9%) | 17/61 (28%) | 3.7 (1.8–8.0) | 0.001 | 4.1 (1.7–9.8) | 0.001 |
Self-reported psychiatric disorder | 26/172 (15%) | 14/61 (23%) | 1.7 (0.81–3.5) | 0.17 | ||
IBS before RYGB | 11/172 (6%) | 16/61 (26%) | 5.2 (2.6–12.0) | < 0.001 | 7.2 (2.8–18.6) | < 0.001 |
Hemoglobin (g/dl) | 14.1 (1.1) | 14.3 (1.1) | 1.1 (0.86–1.5) | 0.41 | ||
Iron (μmol/L) | 15.0 (5.3) | 15.6 (5.1) | 1.0 (0.97–1.1) | 0.43 | ||
Ferritin (μg/L) | 144 (130.3) | 138 (103.8) | 1.0 (0.99–1.0) | 0.74 | ||
White-cell count (×109/liter) | 7.6 (2.1) | 7.7 (2.1) | 1.0 (0.88–1.8) | 0.83 | ||
HbA1C (%) | 6.1 (1.4) | 6.0 (1.4) | 0.94 (0.75–1.8) | 0.58 | ||
Thyroid stimulating hormone (x10E-3 IU/L) | 1.7 (0.95) | 2.2 (1.9) | 1.3 (1.0–1.7) | 0.039 | ||
C-reactive protein (mg/liter) | 7.7 (6.3) | 7.7 (5.5) | 1.0 (0.95–1.1) | 0.99 | ||
Cholesterol (mmol/liter) | 5.0 (1.0) | 4.8 (0.95) | 0.82 (0.61–1.1) | 0.20* | ||
High-density lipoprotein (mmol/liter) | 1.2 (0.31) | 1.2 (0.25) | 0.86 (0.32–2.4) | 0.77 | ||
Low-density lipoprotein (mmol/liter) | 3.2 (0.92) | 3.0 (0.75) | 0.81 (0.58–1.1) | 0.20 | 0.66 (0.45–0.96) | 0.031 |
Triglycerides (mmol/L) | 1.86 (1.4) | 1.88 (1.2) | 1.0 (0.81–1.3) | 0.93 | ||
Vitamin B1 (nmol/liter) | 155 (28.1) | 162 (27.2) | 1.0 (0.99–1.0) | 0.11 | 1.0 (1.0–1.0) | 0.013 |
Vitamin B6 (nmol/liter) | 36.6 (36.9) | 36.0 (27.9) | 1.0 (0.99–1.0) | 0.91 | ||
Vitamin B12 (pmol/liter) | 384 (182) | 350 (110) | 1.0 (1.0–1.0) | 0.17 | ||
Folic acid (nmol/liter) | 20.0 (9.0) | 20.9 (8.8) | 1.0 (0.98–1.0) | 0.50 | ||