Skip to main content

Table 2 Preoperative predictors of irritable bowel syndrome (IBS)-like symptoms 2 years after Roux-en-Y-gastric bypass (RYGB)

From: Irritable bowel syndrome-like symptoms and health related quality of life two years after Roux-en-Y gastric bypass - a prospective cohort study

Preoperative characteristicsPatients without IBS-like symptoms after RYGB
n = 172
Patients with IBS-like symptoms
after RYGB
n = 61
Odds ratio
(95% CI)
Statistics
(p-values)
Adjusted for all significant predictors and center of inclusion
 Odds ratio
(95% CI)
Statistics
(p-values)
Gender (female)127/172 (74%)50/61 (82%)1.6 (0.77–3.4)0.20  
Age (years)43.3 (9.3)43.3 (8.4)1.0 (0.94–1.0)0.66  
Body mass index (kg/m2)42.8 (4.9)43.1 (4.6)1.0 (0.96–1.1)0.65  
Living with partner118/171 (69%)47/61 (77%)1.5 (0.77–3.0)0.24  
Working full time105/171 (61%)28/61 (46%)0.53 (0.30–0.96)0.037  
Smokers39/168 (23%)10/59 (17%)0.68 (0.31–1.5)0.32  
Type 2 diabetes42/172 (24%)15/61 (25%)1.0 (0.51–2.0)0.98  
Hypertension74/171 (43%)25/61 (40%)0.76 (0.50–1.7)0.76  
Hypothyroidism14/172 (8%)8/61 (13%)1.7 (0.68–4.3)0.26  
Fibromyalgia16/171 (9%)17/61 (28%)3.7 (1.8–8.0)0.0014.1 (1.7–9.8)0.001
Self-reported psychiatric disorder26/172 (15%)14/61 (23%)1.7 (0.81–3.5)0.17  
IBS before RYGB11/172 (6%)16/61 (26%)5.2 (2.6–12.0)< 0.0017.2 (2.8–18.6)< 0.001
Hemoglobin (g/dl)14.1 (1.1)14.3 (1.1)1.1 (0.86–1.5)0.41  
Iron (μmol/L)15.0 (5.3)15.6 (5.1)1.0 (0.97–1.1)0.43  
Ferritin (μg/L)144 (130.3)138 (103.8)1.0 (0.99–1.0)0.74  
White-cell count (×109/liter)7.6 (2.1)7.7 (2.1)1.0 (0.88–1.8)0.83  
HbA1C (%)6.1 (1.4)6.0 (1.4)0.94 (0.75–1.8)0.58  
Thyroid stimulating hormone (x10E-3 IU/L)1.7 (0.95)2.2 (1.9)1.3 (1.0–1.7)0.039  
C-reactive protein (mg/liter)7.7 (6.3)7.7 (5.5)1.0 (0.95–1.1)0.99  
Cholesterol (mmol/liter)5.0 (1.0)4.8 (0.95)0.82 (0.61–1.1)0.20*  
High-density lipoprotein (mmol/liter)1.2 (0.31)1.2 (0.25)0.86 (0.32–2.4)0.77  
Low-density lipoprotein (mmol/liter)3.2 (0.92)3.0 (0.75)0.81 (0.58–1.1)0.200.66 (0.45–0.96)0.031
Triglycerides (mmol/L)1.86 (1.4)1.88 (1.2)1.0 (0.81–1.3)0.93  
Vitamin B1 (nmol/liter)155 (28.1)162 (27.2)1.0 (0.99–1.0)0.111.0 (1.0–1.0)0.013
Vitamin B6 (nmol/liter)36.6 (36.9)36.0 (27.9)1.0 (0.99–1.0)0.91  
Vitamin B12 (pmol/liter)384 (182)350 (110)1.0 (1.0–1.0)0.17  
Folic acid (nmol/liter)20.0 (9.0)20.9 (8.8)1.0 (0.98–1.0)0.50  
  1. The results are given as number (proportion in per cent) for categorical variables, and mean (SD) for continuous variables with normal distribution. Preoperative characteristics associated with IBS-like symptoms 2 years after RYGB were studied with univariate regression. Any variable associated from the univariate analysis (with p < 0.25) were entered into a multivariable logistic regression model using a manual backward stepwise elimination procedure. In total, 10 potential predictors were examined in the multivariable analysis (p-values written in bold). Cholesterol was not included in the final analysis due to high correlation with LDL