Irritable bowel syndrome-like symptoms and health related quality of life two years after Roux-en-Y gastric bypass - a prospective cohort study

Table 1 Patient characteristics at the preoperative visit and the 2 year follow-up visit after Roux-en-Y-gastric bypass

	Preoperative visit n = 233	Two year follow-up visit n = 233	Statistics (p-values)
Gender (male/female)	56 (24%)/177 (76%)
Age (years)	43.5 (9.1)
Body mass index (kg/m²)	42.9 (4.9)	29.5 (4.6)	<0.001
Living with partner	161 (71%)	172 (76%)	0.03
Full time work	130 (58%)	127 (56%)	0.78
Type 2 diabetes	55 (24%)	18 (8%)	<0.001
Hypertension	98 (43%)	34 (15%)	<0.001
Hypothyroidism	22 (10%)	24 (10%)	0.73
Fibromyalgia	33 (14%)	36 (16%)	0.61
Self-reported psychiatric disorder	40 (17%)	37 (16%)	0.76
Irritable bowel syndrome	27 (12%)	61 (26%)	<0.001
IBS-constipation	5 (2%)	11 (5%)	0.15
IBS-diarrhea	5 (2%)	12 (5%)	0.09
IBS-mixed	16 (7%)	34 (15%)	0.004
IBS-unsubtyped	1 (0.4%)	3 (1%)	0.63
Hemoglobin (g/dl)	14.2 (1.1)	13.7 (1.1)	<0.001
Iron (mol/L)	15.1 (5.2)	19.6 (6.9)	<0.001
Ferritin	104.5 (8–584)	115.0 (4–804)	0.31
White-cell count (×10⁹/liter)	7.7 (2.1)	6.2 (1.9)	<0.001
HbA_1c (%)	5.7 (4.6–14.9)	5.2 (4.0–9.7)	<0.001
C-reactive protein (mg/liter)	7.0 (0–50.0)	0.6 (0–66.0)	<0.001
Cholesterol (mmol/liter)	4.9 (1.0)	4.3 (0.7)	<0.001
High-density lipoprotein (mmol/liter)	1.2 (0.3)	1.7 (0.4)	<0.001
Low-density lipoprotein (mmol/liter)	3.2 (0.9)	2.5 (0.7)	<0.001
Triglycerides	1.9 (1.3)	1.0 (0.5)	<0.001
Vitamin B₁ (nmol/liter)	157.4 (27.8)	159.6 (27.7)	0.18
Vitamin B₆ (nmol/liter)	36.5 (34.9)	52.8 (44.0)	<0.001
Vitamin B₁₂ (pmol/liter)	375.8 (166.8)	531.4 (321.3)	<0.001
Folic acid (nmol/liter)	20.3 (9.0)	22.2 (10.6)	0.014

The results are given as number (proportion in per cent) for categorical variables, mean (SD) for continuous variables with normal distribution and median (min-max) for other variables. Significant p-values are marked in bold
Data were analyzed with McNemar test for categorical variables and paired t-tests or Wilcoxon signed-rank test (marked with†) for continuous variables
For one patient, we had insufficient information for subtyping of IBS at the 2 year follow-up visit
Missing variables: Living with partner (n = 7), Full time work (n = 7), type 2 diabetes (n = 3), Hypertension (n = 4) Hypothyroidism (n = 4), Fibromyalgia (n = 4), minor psychiatric disorder (n = 4), Hemoglobin (=2), Iron (n = 2), Ferritin (n = 7), White-cell count (n = 3), HbA1c (n = 2), CRP (n = 3), Cholesterol (n = 2), High-density lipoprotein (n = 2), Low-density lipoprotein (n = 2), Triglycerides (n = 2), Vitamin B1 (n = 4), Vitamin B6 (n = 4), Vitamin B12 (n = 2), Folic acid (n = 2)
*Two de-novo diabetes mellitus

ISSN: 1471-230X