Table 1 Univariate analysis of the prognosis of gastric cancer after D2 radical resection for 421 cases
Factors | Subgroups | n(%) | Univariate analysis | ||
|---|---|---|---|---|---|
HR | 95%CI | p | |||
Age | – | 421 (100) | 1.227 | .999–1.505 | .051 |
Gender | Male | 306 (72.7) | 1 | ||
Female | 115 (27.3) | 1.110 | .812–1.517 | .512 | |
Staging | I | 90 (21.4) | 1 | ||
II | 109 (25.9) | 2.846 | 1.484–5.458 | .002 | |
III | 222 (52.7) | 7.618 | 4.217–13.763 | .000 | |
Tumor site | Proximal | 51 (12.1) | 1 | ||
Gastric body | 59 (14.0) | .664 | .408–1.081 | .099 | |
Antrum | 281 (66.7) | .444 | .305–0.645 | .000 | |
Total stomach | 30 (7.1) | .857 | .493–1.492 | .587 | |
Pathological type | Adenocarcioma | 369 (87.6) | 1 | ||
Mucous carcinoma | 15 (3.6) | .919 | .431–1.958 | .827 | |
Gastric signet ring cell carcinoma | 15 (3.6) | 1.320 | .675–2.581 | .418 | |
Undifferentiated tumor | 22 (5.2) | .973 | .528–1.791 | .929 | |
Tumor size (cm) | – | – | 1.124 | 1.079–1.170 | .000 |
Neural invasion | No | 284 (67.5) | 1 | ||
Yes | 137 (32.5) | 2.535 | 1.901–3.382 | .000 | |
Vessel invasion | No | 271 (64.4) | 1 | ||
Yes | 150 (35.6) | 2.909 | 2.187–3.870 | .000 | |
Borrmann type | I | 19 (4.5) | 1 | ||
II | 105 (24.9) | 1.550 | .464–5.182 | .476 | |
III | 218 (51.8) | 4.995 | 1.588–15.717 | .006 | |
IV | 79 (18.8) | 6.106 | 1.900–19.620 | .002 | |
Number of lymph nodes metastasis | – | 421 (100) | 1.074 | 1.058–1.090 | .000 |
Total lymph nodes | – | 421 (100) | 1.018 | 1.004–1.032 | .014 |
The rate of positive lymph nodes | – | 421 (100) | 12.072 | 7.514–19.393 | .000 |
BMI(kg/m2) | < 18.5 | 66 (15.7) | 1 | ||
18.5–24.0 | 283 (67.2) | .560 | .396–0.793 | .001 | |
≥24.0 | 72 (17.1) | .393 | .241–0.640 | .000 | |
Variation of coeliac artery | No | 311 (73.9) | 1 | ||
Yes | 110 (26.1) | 1.039 | .755–1.430 | .815 | |
Hb(g/L) | < 130 | 295 (70.1) | 1 | ||
≥130 | 126 (29.9) | .803 | .585–1.104 | .177 | |
PLT(109/L) | < 125 | 16 (3.8) | 1 | ||
125–350 | 335 (79.6) | .736 | .376–1.442 | .372 | |
> 350 | 70 (16.6) | .892 | .428–1.861 | .761 | |
NEU(109/L) | < 1.8 | 17 (4.0) | 1 | ||
1.8–6.3 | 361 (85.7) | .590 | .320–1.088 | .091 | |
> 6.3 | 43 (10.2) | .701 | .341–1.441 | .334 | |
LYM(109/L) | < 1.1 | 44 (10.5) | 1 | ||
1.1–3.2 | 373 (88.6) | .606 | .403–0.910 | .016 | |
> 3.2 | 4 (1.0) | .893 | .121–6.597 | .912 | |
NLR | < 2.37 | 252 (59.9) | 1 | ||
≥2.37 | 169 (40.1) | 1.153 | .869–1.531 | .324 | |
Alb(g/L) | < 35 | 121 (28.7) | 1 | ||
≥35 | 300 (71.3) | .587 | .440–0.783 | .000 | |
AFP(μg/L) | < 20 | 407 (96.7) | 1 | ||
≥20 | 14 (3.3) | 1.331 | .656–2.703 | .428 | |
CEA(μg/L) | < 5 | 341 (81.0) | 1 | ||
≥5 | 80 (19.0) | 1.986 | 1.446–2.726 | .000 | |
CA125(kU/L) | < 35 | 396 (94.1) | 1 | ||
≥35 | 25 (5.9) | 1.555 | .885–2.731 | .125 | |
CA153(kU/L) | < 31.3 | 412 (97.9) | 1 | ||
≥31.3 | 9 (2.1) | 2.789 | 1.372–5.669 | .005 | |
CA199(kU/L) | < 37 | 352 (83.6) | 1 | ||
≥37 | 69 (16.4) | 2.479 | 1.786–3.442 | .000 | |