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Table 3 HLA-DQ data in relation to clinical and analytical features stratified by family history in CD

From: Influence of HLA on clinical and analytical features of pediatric celiac disease

  Sex n = 463 Clinical Presentation n = 463 Histological Damage n = 458 Anti-TG2/EMA n = 275 Anti-TG2 Levels n = 172
M F Classical Non-Classical M3b + M3c Milder lesion Positive Negative ≥100 < 100
Family History HLA-DQ2.5 double dose 10 66.7% 5 33.3% 4 28.6% 10 71.4% 13 92.9% 1 7.1% 12 100% 0 6 75% 2 25%
Other HLA-DQ 3 42.9% 4 57.1% 3 37.5% 5 62.5% 8 100% 0 5 100% 0 3 60% 2 40%
Non-Family History HLA-DQ2.5 double dose 68 39.1% 106 60.9% 162 92.6% 13 7.4% 164 94.8% 9 5.2% 110 99.1% 1 0.9% 43 70.5% 18 29.5%
Other HLA-DQ 94 35.2% 173 64.8% 229 86.1% 37 13.9% 232 88.2% 31 11.8% 153 93.3% 11 6.7% 67 68.4% 31 31.6%