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Fig. 1 | BMC Gastroenterology

Fig. 1

From: The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis

Fig. 1

The stanniocalcin-2/PAPP-A/IGFBP-4 axis. Left: PAPP-A cleaves IGFBP-4 into two fragments in the vicinity of the IGF-IR, resulting in liberation of bioactive IGF that can activate its receptor. Right: stanniocalcin-2 inhibits PAPP-A degradation of IGFBP-4, resulting in decreased levels of bioactive IGF and consequently reduced IGF signaling. IGF, insulin-like growth factor; IGF-IR, IGF-I receptor; IGFBP, IGF binding protein; PAPP-A, pregnancy-associated plasma protein-A; STC2, Stanniocalcin-2

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BMC Gastroenterology

ISSN: 1471-230X

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