Fig. 4

OCA treatment improves liver function and lipid metabolism in FATZO mice fed WDF. (a) Body weight, (b) blood triglyceride, (c) total cholesterol, (d) LDL, (e) ALT, (f) AST, (g) liver weight, and (h) hepatic triglyceride content in WDF fed FATZO mice treated with vehicle or OCA (30 mg/kg, QD). Data were presented as mean ± SEM. ^ap < 0.05, ^aap < 0.01, ^aaap < 0.005vs vehicle controls using two-way ANOVA with Dunnett’s post hoc comparison (a-f) or unpaired student t-test (g, h)