Elevated D-dimer is associated with increased 28-day mortality in acute-on-chronic liver failure in China: a retrospective study

Table 5 Odds ratios for 28-day mortality per unit increase in D-dimer in subgroups of patients

	No. of events	Non-adjusted	P for interaction	Adjust I	P for interaction	Adjust II	P for interaction
Cirrhosis
yes	63	1.4 (1.1, 1.8) 0.004	0.948	1.4 (1.1, 1.9) 0.016	0.479	1.4 (1.0, 2.0) 0.088	0.866
no	52	1.4 (1.1, 1.9) 0.018		1.2 (0.8, 1.8) 0.361		1.5 (0.9, 2.4) 0.138
EASL-ACLF
yes	59	1.6 (1.2, 2.1) 0.002	0.452	1.4 (1.0, 2.0) 0.039	0.797	1.4 (0.9, 2.3) 0.128	0.886
no	56	1.4 (1.0, 1.8) 0.040		1.3 (0.9, 1.9) 0.105		1.4 (0.9, 2.1) 0.168
Coagulation failure
yes	43	1.4 (1.0, 1.9) 0.024	0.688	1.2 (0.8, 1.6) 0.328	0.259	1.3 (0.7, 2.4) 0.322	0.623
no	72	1.5 (1.2, 2.0) 0.003		1.5 (1.1, 2.1) 0.009		1.6 (1.0, 2.8) 0.060
Hepatic encephalopathy
yes	31	1.3 (1.0, 1.8) 0.087	0.496	1.1 (0.8, 1.6) 0.648	0.161	1.1 (0.7, 1.6) 0.797	0.202
no	84	1.5 (1.2, 1.9) 0.001		1.5 (1.1, 2.0) 0.005		1.6 (1.1, 2.3) 0.015
leukocyte counts
< 4 × 10⁹/L or > 12 × 10⁹/L	28	1.7 (1.1, 2.6) 0.010	0.263	1.7 (1.0, 2.9) 0.054	0.254	2.1 (0.9, 4.5) 0.075	0.156
4 × 10⁹/L - 12 × 10⁹/L	87	1.3 (1.1, 1.6) 0.007		1.2 (0.9, 1.6) 0.149		1.2 (0.9, 1.8) 0.256

Non-adjusted model adjust for: None
Adjust I model adjust for: age; international normalized ratio; leukocyte counts; serum bilirubin and serum creatinine
Adjust II model adjust for: age, red blood cells, hematocrit, albumin, neutrophil percentage, serum total bilirubin, international normalized ratio, C-reactive protein, hepatic encephalopathy, and ascites

ISSN: 1471-230X