Fig. 2

Formation of RhoA in human CD14+ monocytes upon pH shift from pH 7.6 to pH 6.6. a Activated GTPase RhoA in human CD14+ monocytes upon pH shift from pH 7.6 to pH 6.6 (n = 6). Carriers of rare TT genotype showed the lowest level of RhoA activation compared to heterozygous CT, WT/CC or healthy WT/CC subjects. b Significantly decreased activation of GTPase RhoA in CD14+ monocytes of IBD (WT/CC, CT, TT) patients compared to non-IBD (WT/CC) genotype carriers upon pH shift 7.6 to 6.6. Data points are normalized to pH 7.6 condition (n = 6 non-IBD, n = 18 IBD). Each dot represents a single patient, one-way ANOVA, t-test, * p < 0.05. No significant differences between carriers of different alleles were identified. IBD: inflammatory bowel disease, WT: Wild type