Skip to main content

Advertisement

Table 2 Univariate and multivariate Cox regression analyses in patients with acute decompensation of CHB cirrhosis from the derivation cohort (n = 509)

From: Development and external validation of a prognostic nomogram for acute decompensation of chronic hepatitis B cirrhosis

  Univariate analysis Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
Age (yr) 1.054(1.031–1.079) < 0.001 1.057(1.032–1.082) < 0.001
Male sex 2.350(1.391–3.969) < 0.001   
Mean arterial pressure (mm Hg) 0.979(0.953–1.005) 0.116   
Previous decompensation 2.419(1.420–4.120) 0.001 2.449(1.351–4.438) 0.002
Complication
 Hyponatremia 4.005(2.351–6.823) < 0.001   
 Ascites 0.463(0.113–1.900) < 0.001   
 Bacteria infection 2.479(1.443–4.259) 0.001 5.325(3.015–9.405) < 0.001
 Gastrointestinal hemorrhage 2.301(1.042–5.081) 0.039   
 Hepatic encephalopathy I-II 1.426(0.439–4.631) 0.555   
 Hepatic encephalopathy III-IV 22.381(10.893–45.983) < 0.001 4.660(3.115–6.972) < 0.001
 Spontaneous bacterial peritonitis 4.392(1.988–9.703) < 0.001   
 Hepatorenal syndrome 6.345(3.617–11.129) < 0.001   
Organ failures
 Liver 2.720(1.583–4.672) < 0.001   
 Kidney 4.839(2.370–9.881) < 0.001   
 Cerebral 20.324(10.909–37.863) < 0.001   
 Coagulation 9.389(5.547–16.891) < 0.001   
 Circulation 10.148(3.657–28.166) < 0.001   
 Lung 9.706(3.024–31.154) < 0.001   
Biochemical parameters
 Alanine aminotransferase (U/L) 1.000(1.000–1.001) 0.298   
 Aspartate aminotransferase (U/L) 1.001(1.000–1.002) 0.005   
 γ-Glutamyltransferase (U/L) 0.999(0.996–1.003) 0.722   
 Albumin (g/L) 0.937(0.890–0.987) 0.015   
 Total bilirubin (mg/dL) 1.048(1.029–1.067) < 0.001 1.053(1.030–1.078) < 0.001
 Serum creatinine (μmol/L) 1.005(1.003–1.007) < 0.001   
 Serum sodium (mmol/L) 0.904(0.872–0.937) < 0.001   
 International normalized ratio 1.963(1.683–2.290) < 0.001   
 White blood cell count (×109/L) 1.151(1.108–1.195) < 0.001   
 Neutrophil count (×109/L) 1.175(1.128–1.225) < 0.001   
 Platelet (× 109/L) 0.998(0.993–1.004) 0.576   
 HBV-DNA (log copies/ml) 1.160(0.986–1.366) 0.074