| |
M1
|
M2
|
M3
|
M4
|
M5
|
M6
|
|---|
|
ALE
|
5.3** [4.1 to 6.9]
|
5.1** [3.9 to 6.7]
|
3.9** [2.9 to 5.2]
|
4.0** [3.0 to 5.4]
|
4.2** [3.2 to 5.6]
|
3.7** [2.8 to 5.0]
|
|
Male
|
–
|
2.1** [1.7 to 2.5]
|
2.0** [1.6 to 2.5]
|
2.1** [1.7 to 2.6]
|
2.0** [1.6 to 2.4]
|
2.4** [1.9 to 3.0]
|
|
Age (years) / 10
|
–
|
1.8** [1.6 to 2.0]
|
1.6** [1.4 to 1.8]
|
1.5** [1.4 to 1.7]
|
1.5** [1.4 to 1.7]
|
1.4** [1.3 to 1.6]
|
|
BMI (kg/m2) / 5
|
–
|
–
|
3.9** [3.3 to 4.5]
|
–
|
–
|
–
|
|
Alcohol intake (units)
|
–
|
–
|
1.0 [0.9 to 1.0]
|
1.0 [1.0 to 1.1]
|
–
|
–
|
|
Waist circumference (cm) / 10
|
–
|
–
|
–
|
2.5** [2.3 to 2.8]
|
–
|
–
|
|
Metabolic syndrome
|
–
|
–
|
–
|
–
|
5.1** [4.1 to 6.3]
|
–
|
|
Large waist circumference
|
–
|
–
|
–
|
–
|
–
|
2.9** [2.3 to 3.8]
|
|
High triglycerides
|
–
|
–
|
–
|
–
|
–
|
3.1** [2.4 to 3.9]
|
|
Low HDL
|
–
|
–
|
–
|
–
|
–
|
1.6* [1.2 to 2.2]
|
|
High blood pressure
|
–
|
–
|
–
|
–
|
–
|
1.9** [1.5 to 2.3]
|
|
High glucose
|
–
|
–
|
–
|
–
|
–
|
2.0** [1.5 to 2.6]
|
|
n
|
2159
|
2159
|
2159
|
2159
|
2159
|
2159
|
|
AIC
|
2750
|
2595
|
2131
|
2244
|
2376
|
2266
|
|
BIC
|
2762
|
2618
|
2165
|
2278
|
2405
|
2317
|
|
ROC-AUC
|
0.61
|
0.72
|
0.83
|
0.81
|
0.79
|
0.81
|
|
Pseudo-R2 (Nagelkerke)
|
0.11
|
0.20
|
0.42
|
0.37
|
0.31
|
0.36
|
- Values are odds ratios and 95% confidence intervals (logistic regression)
- Abbreviations: M# model number, ALE altered liver enzymes, BMI body mass index, HDL high-density lipoprotein, AIC Akaike information criterion, BIC Bayesian information criterion, ROC-AUC area under the ROC curve, pseudo-R2 pseudo-squared R
- *p < 0.01; **p < 0.001
