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Table 1 Characteristics of IBD patients with or without biologic treatment

From: Biologic treatment of Japanese patients with inflammatory bowel disease

Characteristics Crohn’s disease Ulcerative Colitis
All, n (%) Biologics users, n (%) Non-biologics users, n (%) P-value All, n (%) Biologics users, n (%) Non-biologics users, n (%) P-value
Patients 235 (23) 113 (48) 122 (52)   800 (77) 63 (8) 737 (92)  
Age (mean ± SD) 42.27 ± 9.95 40.82 ± 9.09 44.00 ± 10.49 0.014 46.19 ± 10.83 45.25 ± 11.83 46.27 ± 10.74 0.474
  ≤ 40 years 102 (43) 55 (49) 47 (39)   251 (31) 24 (38) 227 (31)  
 41–65 years 124 (53) 55 (49) 69 (57)   466 (58) 34 (54) 432 (59)  
  > 65 years 9 (4) 3 (2) 6 (4)   83 (11) 5 (8) 78 (10)  
Gender     0.521     0.285
 Male 168 (71) 83 (73) 85 (70)   507 (63) 36 (57) 471 (64)  
 Female 67 (29) 30 (27) 37 (30)   293 (37) 27 (43) 266 (36)  
Marriage status     0.253     0.335
 Married 124 (53) 64 (57) 60 (49)   261 (33) 24 (38) 237 (32)  
 Single 111 (47) 49 (43) 62 (51)   539 (77) 39 (62) 500 (68)  
Highest Education     0.010     0.973
 College or less 136 (58) 73 (65) 63 (52)   383 (48) 31 (49) 352 (48)  
 Bachelor’s degree 84 (36) 38 (34) 46 (38)   363 (45) 28 (44) 335 (45)  
 Master’s degree 15 (6) 2 (1) 13 (10)   54 (7) 4 (6) 50 (7)  
Occupation     0.645     0.986
 Fulltime 130 (55) 64 (57) 66 (54)   450 (56) 34 (54) 416 (56)  
 Part-time 19 (8) 8 (7) 11 (9)   76 (10) 7 (11) 69 (9)  
 Self employed 20 (9) 7 (6) 13 (11)   59 (7) 6 (10) 53 (7)  
 House wife/house keeper 24 (10) 11 (10) 13 (11)   103 (13) 8 (13) 95 (13)  
 Student 2 (1) 2 (2) 0 (0)   2 (0) 0 (0) 3 (0)  
 Unemployed/Pensioner 38 (16) 20 (18) 18 (15)   94 (12) 7 (11) 87 (12)  
 Others 2 (1) 1 (0) 1 (0)   15 (2) 1 (1) 14 (3)  
Household incomes     0.967     0.427
  < 2 M JPY 23 (10) 11 (10) 12 (10)   72 (9) 4 (6) 68 (9)  
 2–4 M JPY 47 (20) 21 (19) 26 (21)   144 (18) 13 (21) 131 (18)  
 4–6 M JPY 55 (24) 25 (22) 30 (25)   185 (23) 16 (26) 169 (23)  
 6–8 M JPY 36 (15) 20 (18) 16 (13)   135 (17) 9 (14) 126 (17)  
 8–10 M JPY 24 (10) 11 (10) 13 (11)   75 (9) 2 (3) 73 (10)  
  > 10 M JPY 19 (8) 9 (8) 10 (8)   85 (11) 7 (11) 78 (11)  
 Not revealed 31 (13) 16 (13) 15 (12)   104 (13) 12 (19) 92 (12)  
Comorbidity
 Dyslipidemia 34 (14) 9 (8) 25 (20) 0.006 83 (10) 10 (16) 73 (10) 0.136
 Hypertension 38 (16) 10 (9) 28 (23) 0.003 108 (14) 15 (24) 93 (13) 0.013
 COPD Asthma 13 (6) 5 (4) 8 (7) 0.475 28 (4) 9 (14) 19 (3) < 0.001
 Diabetes 16 (7) 5 (4) 11 (9) 0.163 56 (7) 13 (21) 43 (6) < 0.001
 Depression 17 (7) 5 (4) 12 (10) 0.110 48 (6) 4 (6) 44 (6) 0.903
 OA and RA 12 (5) 4 (4) 8 (7) 0.294 32 (4) 9 (14) 23 (3) < 0.001
 Gastrointestinal disease 15 (6) 5 (4) 10 (8) 0.237 49 (6) 11 (18) 38 (5) < 0.001
Current treatment
 Nutritional 137 (58) 65 (58) 72 (59) 0.816 107 (13) 18 (28) 89 (12) < 0.001
 5-ASA 168 (71) 82 (73) 86 (70) 0.725 656 (82) 56 (89) 600 (81) 0.138
 Steroid 39 (17) 16 (14) 23 (19) 0.334 127 (16) 21 (33) 106 (14) < 0.001
 immunomodulator 53 (23) 30 (27) 23 (19) 0.158 61 (8) 27 (43) 64 (9) < 0.001
 Biologic agents 112 (48)   56 (7)  
 Cytapheresis 1 (0) 0 (0) 1 (1) 0.335 16 (2) 7 (11) 9 (1) < 0.001
Surgical history
 Yes 146 (62) 72 (64) 74 (61) 0.629 94 (12) 13 (21) 81 (11) 0.023
Time since diagnosis     0.179     0.267
 0–2 years 27 (11) 8 (7) 19 (16)   134 (17) 7 (11) 127 (17)  
 3–8 years 66 (28) 34 (30) 31 (25)   296 (37) 30 (48) 266 (36)  
 9–15 years 44 (19) 24 (21) 20 (16)   197 (25) 15 (24) 182 (25)  
  > 15 years 99 (42) 47 (42) 52 (43)   173 (22) 11 (17) 162 (22)  
Type of hospitals     0.657     0.001
 University hospital 92 (39) 41 (36) 51 (42)   160 (20) 25 (40) 135 (18)  
 General/Specialist hospital 128 (55) 65 (57) 63 (52)   410 (51) 26 (41) 384 (52)  
 Clinics 15 (6) 7 (7) 8 (6)   229 (29) 12 (19) 217 (30)  
 Others 0 (0) 0 (0) 0 (0)   1 (0) 0 (0) 1 (0)  
Frequency of visit     < 0.001     < 0.001
 More than once a month 38 (16) 11 (10) 27 (22)   61 (8) 16 (24) 46 (6)  
 Once every month 73 (31) 29 (26) 44 (36)   281 (35) 27 (43) 254 (35)  
 Once every 2 months 94 (40) 69 (61) 25 (20)   247 (31) 20 (32) 227 (31)  
 Less than every 2 months 30 (13) 4 (3) 26 (22)   211 (26) 1 (1) 210 (28)  
  1. COPD, chronic obstructive pulmonary disease; OA, osteoarthritis; RA, rheumatoid arthritis; M JPY, million Japanese Yen; SD, standard deviation