Table 1 Characteristics of IBD patients with or without biologic treatment
From: Biologic treatment of Japanese patients with inflammatory bowel disease
Characteristics | Crohn’s disease | Ulcerative Colitis | ||||||
|---|---|---|---|---|---|---|---|---|
All, n (%) | Biologics users, n (%) | Non-biologics users, n (%) | P-value | All, n (%) | Biologics users, n (%) | Non-biologics users, n (%) | P-value | |
Patients | 235 (23) | 113 (48) | 122 (52) | 800 (77) | 63 (8) | 737 (92) | ||
Age (mean ± SD) | 42.27 ± 9.95 | 40.82 ± 9.09 | 44.00 ± 10.49 | 0.014 | 46.19 ± 10.83 | 45.25 ± 11.83 | 46.27 ± 10.74 | 0.474 |
≤ 40 years | 102 (43) | 55 (49) | 47 (39) | 251 (31) | 24 (38) | 227 (31) | ||
41–65 years | 124 (53) | 55 (49) | 69 (57) | 466 (58) | 34 (54) | 432 (59) | ||
> 65 years | 9 (4) | 3 (2) | 6 (4) | 83 (11) | 5 (8) | 78 (10) | ||
Gender | 0.521 | 0.285 | ||||||
Male | 168 (71) | 83 (73) | 85 (70) | 507 (63) | 36 (57) | 471 (64) | ||
Female | 67 (29) | 30 (27) | 37 (30) | 293 (37) | 27 (43) | 266 (36) | ||
Marriage status | 0.253 | 0.335 | ||||||
Married | 124 (53) | 64 (57) | 60 (49) | 261 (33) | 24 (38) | 237 (32) | ||
Single | 111 (47) | 49 (43) | 62 (51) | 539 (77) | 39 (62) | 500 (68) | ||
Highest Education | 0.010 | 0.973 | ||||||
College or less | 136 (58) | 73 (65) | 63 (52) | 383 (48) | 31 (49) | 352 (48) | ||
Bachelor’s degree | 84 (36) | 38 (34) | 46 (38) | 363 (45) | 28 (44) | 335 (45) | ||
Master’s degree | 15 (6) | 2 (1) | 13 (10) | 54 (7) | 4 (6) | 50 (7) | ||
Occupation | 0.645 | 0.986 | ||||||
Fulltime | 130 (55) | 64 (57) | 66 (54) | 450 (56) | 34 (54) | 416 (56) | ||
Part-time | 19 (8) | 8 (7) | 11 (9) | 76 (10) | 7 (11) | 69 (9) | ||
Self employed | 20 (9) | 7 (6) | 13 (11) | 59 (7) | 6 (10) | 53 (7) | ||
House wife/house keeper | 24 (10) | 11 (10) | 13 (11) | 103 (13) | 8 (13) | 95 (13) | ||
Student | 2 (1) | 2 (2) | 0 (0) | 2 (0) | 0 (0) | 3 (0) | ||
Unemployed/Pensioner | 38 (16) | 20 (18) | 18 (15) | 94 (12) | 7 (11) | 87 (12) | ||
Others | 2 (1) | 1 (0) | 1 (0) | 15 (2) | 1 (1) | 14 (3) | ||
Household incomes | 0.967 | 0.427 | ||||||
< 2 M JPY | 23 (10) | 11 (10) | 12 (10) | 72 (9) | 4 (6) | 68 (9) | ||
2–4 M JPY | 47 (20) | 21 (19) | 26 (21) | 144 (18) | 13 (21) | 131 (18) | ||
4–6 M JPY | 55 (24) | 25 (22) | 30 (25) | 185 (23) | 16 (26) | 169 (23) | ||
6–8 M JPY | 36 (15) | 20 (18) | 16 (13) | 135 (17) | 9 (14) | 126 (17) | ||
8–10 M JPY | 24 (10) | 11 (10) | 13 (11) | 75 (9) | 2 (3) | 73 (10) | ||
> 10 M JPY | 19 (8) | 9 (8) | 10 (8) | 85 (11) | 7 (11) | 78 (11) | ||
Not revealed | 31 (13) | 16 (13) | 15 (12) | 104 (13) | 12 (19) | 92 (12) | ||
Comorbidity | ||||||||
Dyslipidemia | 34 (14) | 9 (8) | 25 (20) | 0.006 | 83 (10) | 10 (16) | 73 (10) | 0.136 |
Hypertension | 38 (16) | 10 (9) | 28 (23) | 0.003 | 108 (14) | 15 (24) | 93 (13) | 0.013 |
COPD Asthma | 13 (6) | 5 (4) | 8 (7) | 0.475 | 28 (4) | 9 (14) | 19 (3) | < 0.001 |
Diabetes | 16 (7) | 5 (4) | 11 (9) | 0.163 | 56 (7) | 13 (21) | 43 (6) | < 0.001 |
Depression | 17 (7) | 5 (4) | 12 (10) | 0.110 | 48 (6) | 4 (6) | 44 (6) | 0.903 |
OA and RA | 12 (5) | 4 (4) | 8 (7) | 0.294 | 32 (4) | 9 (14) | 23 (3) | < 0.001 |
Gastrointestinal disease | 15 (6) | 5 (4) | 10 (8) | 0.237 | 49 (6) | 11 (18) | 38 (5) | < 0.001 |
Current treatment | ||||||||
Nutritional | 137 (58) | 65 (58) | 72 (59) | 0.816 | 107 (13) | 18 (28) | 89 (12) | < 0.001 |
5-ASA | 168 (71) | 82 (73) | 86 (70) | 0.725 | 656 (82) | 56 (89) | 600 (81) | 0.138 |
Steroid | 39 (17) | 16 (14) | 23 (19) | 0.334 | 127 (16) | 21 (33) | 106 (14) | < 0.001 |
immunomodulator | 53 (23) | 30 (27) | 23 (19) | 0.158 | 61 (8) | 27 (43) | 64 (9) | < 0.001 |
Biologic agents | 112 (48) | – | – | 56 (7) | – | – | ||
Cytapheresis | 1 (0) | 0 (0) | 1 (1) | 0.335 | 16 (2) | 7 (11) | 9 (1) | < 0.001 |
Surgical history | ||||||||
Yes | 146 (62) | 72 (64) | 74 (61) | 0.629 | 94 (12) | 13 (21) | 81 (11) | 0.023 |
Time since diagnosis | 0.179 | 0.267 | ||||||
0–2 years | 27 (11) | 8 (7) | 19 (16) | 134 (17) | 7 (11) | 127 (17) | ||
3–8 years | 66 (28) | 34 (30) | 31 (25) | 296 (37) | 30 (48) | 266 (36) | ||
9–15 years | 44 (19) | 24 (21) | 20 (16) | 197 (25) | 15 (24) | 182 (25) | ||
> 15 years | 99 (42) | 47 (42) | 52 (43) | 173 (22) | 11 (17) | 162 (22) | ||
Type of hospitals | 0.657 | 0.001 | ||||||
University hospital | 92 (39) | 41 (36) | 51 (42) | 160 (20) | 25 (40) | 135 (18) | ||
General/Specialist hospital | 128 (55) | 65 (57) | 63 (52) | 410 (51) | 26 (41) | 384 (52) | ||
Clinics | 15 (6) | 7 (7) | 8 (6) | 229 (29) | 12 (19) | 217 (30) | ||
Others | 0 (0) | 0 (0) | 0 (0) | 1 (0) | 0 (0) | 1 (0) | ||
Frequency of visit | < 0.001 | < 0.001 | ||||||
More than once a month | 38 (16) | 11 (10) | 27 (22) | 61 (8) | 16 (24) | 46 (6) | ||
Once every month | 73 (31) | 29 (26) | 44 (36) | 281 (35) | 27 (43) | 254 (35) | ||
Once every 2 months | 94 (40) | 69 (61) | 25 (20) | 247 (31) | 20 (32) | 227 (31) | ||
Less than every 2 months | 30 (13) | 4 (3) | 26 (22) | 211 (26) | 1 (1) | 210 (28) | ||