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Table 3 Evaluation of the diagnostic accuracy of the evaluated strategies for significant colonic lesion detection

From: Symptom or faecal immunochemical test based referral criteria for colorectal cancer detection in symptomatic patients: a diagnostic tests study

 

Sensititvity1

P2

Specificity1

P3

Positive PV1

Negative PV1

Positive LR4

Negative LR4

Diagnostic OR4

2017 NG12 referral criteria (n = 1479)

98.9%

(97.3–99.6)

 

7.9%

(6.4–9.7)

 

30.9% (28.6–33.4)

94.6%

(87.3–98.0)

1.07

(1.05–1.10)

0.14

(0.06–0.3)

7.9

(3.2–19.5)

CG27 referral criteria (n = 821)

58.3%

(53.6–62.8)

p < 0.001

50.3%

(47.3–53.3)

p < 0.001

32.9% (29.7–36.2)

74.3%

(71.0–77.4)

1.17

(1.07–1.29)

0.83

(0.73–0.94)

1.4

(1.1–1.7)

f-Hb ≥ 20 μg Hb/g faeces (n = 607)

74.2%

(70.0–78.1)

p < 0.001

76.1%

(73.5–78.6)

p < 0.001

56.5% (52.4–60.5)

87.6%

(85.3–89.6)

3.11

(2.76–3.50)

0.34

(0.29–0.40)

9.2

(7.1–11.8)

f-Hb ≥ 10 μg Hb/g faeces (n = 696)

79.4%

(75.4–83.0)

p < 0.001

70.2%

(67.4–72.9)

p < 0.001

52.7% (49.0–56.5)

89.1%

(86.8–91.0)

2.67

(2.41–2.95)

0.29

(0.24–0.35)

9.1

(7.0–11.8)

COLONPREDICT Score ≥ 5.6 (n = 463)

64.2%

(59.5–68.5)

p < 0.001

83.1%

(80.7–85.2)

p < 0.001

61.4% (56.9–65.8)

84.7%

(82.3–86.7)

3.79

(3.27–4.40)

0.43

(0.38–0.49)

8.8

(6.8–11.3)

COLONPREDICT Score ≥ 3.2 (n = 994)

88.7%

(85.3–91.4)

p < 0.001

51.3%

(48.3–54.3)

p < 0.001

43.3% (40.1–46.6)

91.5%

(89.0–93.6)

1.82

(1.70–1.95)

0.22

(0.17–0.29)

8.3

(6.0–11.3)

FAST Score ≥ 4.50 (n = 583)

72.7%

(68.4–76.7)

p < 0.001

77.8%

(75.2–80.2)

p < 0.001

57.8%

(53.7–61.9)

87.2%

(84.9–89.2)

3.28

(2.90–3.71)

0.35

(0.30–0.41)

9.4

(7.3–12.0)

FAST Score ≥ 2.12 (n = 1383)

97.8% (95.9–98.9)

p = 1

16.1%

(14.0–18.4)

p < 0.001

32.8%

(30.3–35.3)

94.7%

(90.2–97.3)

1.17

(1.13–1.2)

0.13

(0.07–0.25)

8.7

(4.5–16.5)

  1. 1Values are expressed as percentages and its 95% confidence interval
  2. 2Significance of the sensitivity differences when compared with the NG12 referral criteria in McNemar’s test. Differences with p < 0.05 are considered statistically significant
  3. 3Significance of the specificity differences when compared with the NG12 referral criteria in McNemar’s test. Differences with p < 0.05 are considered statistically significant
  4. 4Values are expressed as absolute numbers and its 95% confidence interval
  5. PV, predictive value; LR, likelihood ratio; OR, odds ratio; f-Hb, faecal haemoglobin; NE, non evaluable
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BMC Gastroenterology

ISSN: 1471-230X

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