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Table 5 Univariate and multivariate analysis of factors with PFS in gastric GIST using Cox proportional hazards regression modeling (n = 98)

From: Secreted protein acidic and rich in cysteine-like 1 suppresses metastasis in gastric stromal tumors

Variables P univariate Multivariate analysis
HR (95% CI) P
Surgical margins    
 R0   Reference  
Not R0 < 0.001 7.266(1.222~ 43.221) 0.029
Multivisceral resection    
No   Reference  
Yes < 0.001 1.553(0.439~ 5.489) 0.495
Peritoneal metastasis at initial diagnosis    
No   Reference  
Yes < 0.001 2.201(0.512~ 9.466) 0.289
Hepatic metastasis at initial diagnosis    
No   Reference  
Yes 0.003 2.281(0.384~ 13.533) 0.364
Tumor size    
≤6 cm   Reference  
> 6 cm < 0.001 4.518(1.172~ 17.410) 0.028
NIH risk classification    
 Very low/low   Reference  
 Intermediate/high 0.005 1.681(0.309~ 9.155) 0.548
Mitotic count    
 ≤5/50 HPF   Reference  
 6~ 10/50 HPF   3.752(0.379~ 37.105) 0.258
> 10/50 HPF < 0.001 8.924(0.908~ 87.698) 0.060
SPARCL1 expression    
Low   Reference  
High < 0.001 0.157(0.040~ 0.612) 0.008
  1. PFS progression-free survival, GIST gastrointestinal stromal tumors, HR hazard ratio, CI confidential interval, HPF high power field, NIH National Institutes of Health, SPARCL1 secreted protein acidic and rich in cysteine-like protein 1, “Not R0” includes surgeries of R1 and R2 resections