Secreted protein acidic and rich in cysteine-like 1 suppresses metastasis in gastric stromal tumors

BMC Gastroenterology

Table 5 Univariate and multivariate analysis of factors with PFS in gastric GIST using Cox proportional hazards regression modeling (n = 98)

Variables	P univariate	Multivariate analysis
Variables	P univariate	HR (95% CI)	P
Surgical margins
R0		Reference
Not R0	< 0.001	7.266(1.222~ 43.221)	0.029
Multivisceral resection
No		Reference
Yes	< 0.001	1.553(0.439~ 5.489)	0.495
Peritoneal metastasis at initial diagnosis
No		Reference
Yes	< 0.001	2.201(0.512~ 9.466)	0.289
Hepatic metastasis at initial diagnosis
No		Reference
Yes	0.003	2.281(0.384~ 13.533)	0.364
Tumor size
≤6 cm		Reference
> 6 cm	< 0.001	4.518(1.172~ 17.410)	0.028
NIH risk classification
Very low/low		Reference
Intermediate/high	0.005	1.681(0.309~ 9.155)	0.548
Mitotic count
≤5/50 HPF		Reference
6~ 10/50 HPF		3.752(0.379~ 37.105)	0.258
> 10/50 HPF	< 0.001	8.924(0.908~ 87.698)	0.060
SPARCL1 expression
Low		Reference
High	< 0.001	0.157(0.040~ 0.612)	0.008

PFS progression-free survival, GIST gastrointestinal stromal tumors, HR hazard ratio, CI confidential interval, HPF high power field, NIH National Institutes of Health, SPARCL1 secreted protein acidic and rich in cysteine-like protein 1, “Not R0” includes surgeries of R1 and R2 resections

ISSN: 1471-230X