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Table 7 Multivariate analysis of factors associated with En bloc resection, complete resection, and procedure-related perforation

From: Endoscopic submucosal dissection under general anesthesia for superficial esophageal squamous cell carcinoma is associated with better clinical outcomes

Variables En bloc resection Complete resection Perforation
OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
Age 1.009 (0.921–1.105) 0.844 0.9991 (0.944–1.041) 0.713 1.029 (0.948–1.116) 0.494
Tumor location   0.950   0.376   0.647
 Upper thoracic 1   1   1  
 Middle thoracic N/A 0.998 0.822 (0.171–3.959) 0.807 0.483 (0.034–6.948) 0.592
 Lower thoracic N/A 0.998 1.203 (0.276–5.240) 0.805 0.259 (0.020–3.309) 0.298
 Esophagogastric Jx N/A 1.000 0.140 (0.007–2.640) 0.189 N/A 0.999
Tumor morphology   0.734   0.955   0.933
 IIa 1   1   1  
 IIb 4.775 (0.318–71.736) 0.258 0.830 (0.253–2.728) 0.759 N/A 0.998
 IIc N/A 0.998 1.063 (0.225–5.030) 0.939 N/A 0.998
 Mixed N/A 1.000 0.511 (0.024–10.810) 0.666 N/A 1.000
Gross tumor size (cm) 0.294 (0.063–1.374) 0.120 1.320 (0.630–2.768) 0.462 0.907 (0.236–3.488) 0.888
Resected specimen size (cm) 1.147 (0319–4.126) 0.834 0.475 (0.228–0.989) 0.047 1.926 (0.580–6.397) 0.285
Depth of tumor invasion   0.744   0.228   0.924
 Mucosal cancer 1   1   1  
 SM invasion 1.467 (0.147–14.623)   0.567 (0.226–1.427)   0.916 (0.150–5.596)  
Experience of endoscopist   0.098   0.146   0.052
 First 10 esophageal ESDs 1   1   1  
 Further esophageal ESDs 0.226 (0.039–1.315)   0.513 (0.208–1.262)   0.289 (0.082–1.011)  
Method of sedation   0.996   0.011   0.030
 Conscious sedation 1   1   1  
 General anesthesia N/A   3.401 (1.317–8.785)   0.067 (0.006–0.775)  
  1. OR odds ratio, CI confidence interval, ESD endoscopic submucosal dissection