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Table 1 Clinical and laboratory data for patients and controls

From: Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease

  Control
N = 34
NAFLD
N = 22
NAFLD with DIOS
N = 16
CLD
N = 8
CLD-IO
N = 21
Compound heterozygous HH
N = 5
Homozygous HH
N = 12
Gender (F/M) 19/15 8/14 5/11 4/4 6/15 1/4 2/10
Age (y) 40 ± 10* 54 ± 16 59 ± 10 57 ± 8 58 ± 8 59 ± 9 51 ± 6
BMI (kg/m2) 23.3 ± 2.6* 30.4 ± 4.2# 28.1 ± 2.4 27.3 ± 5.1 27.0 ± 4.2 29.0 ± 3.5 28.2 ± 4.8
Hemoglobin (g/L) 142 ± 11 150 ± 15 149 ± 17 140 ± 10 140 ± 17 158 ± 15 154 ± 12
ALT (U/L) 18 ± 6* 94 ± 76 59 ± 41 71 ± 59 53 ± 29 41 ± 35 82 ± 35
CRP (mg/L) 1.1 ± 0.4 3.0 ± 2.9 1.8 ± 0.9 2.8 ± 3.0 3.8 ± 5.5 3.6 ± 4.0 3.3 ± 2.7
Serum ferritin (μg/L) 94 ± 87 304 ± 248 816 ± 285¤ 454 ± 688 1304 ± 1295¤ 878 ± 408¤ 1753 ± 998¤
Transferrin saturation (%) 0.28 ± 0.11 0.28 ± 0.09 0.39 ± 0.09 0.31 ± 0.15 0.50 ± 0.21§ 0.46 ± 0.10§ 0.76 ± 0.21*
Hepatic iron score N.D. 0.11 ± 0.21 2.19 ± 0.95¤ 0.29 ± 0.27 2.98 ± 1.22¤ 3.38 ± 0.75¤ 4.35 ± 0.63¤
  1. CLD chronic liver disease, IO iron overload, HH hereditary hemochromatosis, NAFLD non-alcoholic fatty liver disease, DIOS dysmetabolic iron overload syndrome. Values denote mean ± S.D
  2. *P < 0.05 vs. all other groups
  3. #p < 0.05 vs. Control, CLD, CLD-IO
  4. ¤p < 0.05 vs. Control, NAFLD, CLD
  5. §p < 0.05 vs. Control, NAFLD, DIOS, CLD, homozygous HH