Fig. 1

IFI16 expression levels in PBMCs from patients with ACLF, CHB, and healthy controls. There was a significant increase in IFI16 expression in ACLF patients compared with CHB patients and healthy controls (a). No significant difference was found between the HBeAg (+) and HBeAg (−) groups (b). No significant correlations were found between the IFI16 level and HBV DNA load (c). The expression of IFI16 was significantly negatively correlated with aspartate aminotransferase (AST) (d), serum total bilirubin (TBIL) (e), and the international normalized ratio(INR) (f), and positively correlated with prothrombin time activity (PTA) (g). AST aspartate aminotransferase, CHB chronic hepatitis B, ACLF acute-on-chronic liver failure, HBeAg hepatitis B e antigen, HBV hepatitis B virus, PBMCs peripheral blood mononuclear cells, TBIL total bilirubin, PTA prothrombin time activity, INR international normalized ratio