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Table 6 Histopathological findings of the five patients with unexplained chronic liver disease who underwent liver biopsy

From: Unexplained chronic liver disease in Ethiopia: a cross-sectional study

No Sex Age (yr) General microscopy Parenchymal changes Ishak-score
1 Female 26 Mild portal and lobular hepatitis with sinusoidal lymphocytosis. Variation of hepatic cord thickness.
Normal bile ducts and intact liver plate.
Focal adaptive parenchymal changes with diffuse hepatocyte swelling/ clarification.
No steatosis or haemosiderosis.
Collagen proportionate area: 5%
Proliferation index: 8%
Apoptosis index: 3%
Fibrosis = 2
Necroinflammation = 2
• piecemeal 0
• lobular 1
• confluent 0
• portal 1
2 Male 25 Normal architecture with normal portal areas, no inflammation. Normal bile ducts and intact liver plate. Adaptive parenchymal changes with diffuse hepatocyte swelling/ clarification. No steatosis or haemosiderosis.
Collagen proportionate area: 6% Proliferation index: 12% Apoptosis index: 5%
Fibrosis = 1
Necroinflammation = 0
3 Female 30 Normal architecture with normal portal areas, no inflammation. Normal bile ducts and intact liver plate. Mild adaptive parenchymal changes with diffuse hepatocyte swelling/clarification. No steatosis or haemosiderosis.
Collagen proportionate area: 3% Proliferation index: 6% Apoptosis index: 1%
Fibrosis = 1
Necroinflammation = 1
• piecemeal 0
• lobular 1
• confluent 0
• portal 0
4 Male 25 Normal architecture with normal portal areas, no inflammation. Normal bile ducts and intact liver plate. Adaptive parenchymal changes with diffuse hepatocyte swelling/clarification. No steatosis or haemosiderosis.
Collagen proportionate area: 8% Proliferation index: 15% Apoptosis index: 6%
Fibrosis = 0
Necroinflammation = 0
5 Female 25 Normal architecture with normal portal areas. Normal bile ducts and intact liver plate Mild mixed steatosis ≈ 20% Focal single cell necrosis, a few apoptotic hepatocytes, a few parenchymal granulocytes. No adaptive changes.
Collagen proportionate area: 3% Proliferation index: 3% Apoptosis index: 2%
Fibrosis = 0
Necroinflammation = 1
• piecemeal 0
• lobular 1
• confluent 0
• portal 0