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Table 4 Laboratory findings in the study subjects with chronic liver disease, by aetiology

From: Unexplained chronic liver disease in Ethiopia: a cross-sectional study

Laboratory variable All patients (n = 150) Aetiology known (n = 67) Aetiology unknown (n = 83)
ALT (U/L) 34 (22–55) 41 (24–58) 30 (21–51)*
  > URR 60 (40.0) 34 (50.7) 26 (31.3)*
AST (U/L) 44 (28–81) 52 (31–83) 41 (28–78)
  > URR 84 (56.0) 41 (61.2) 43 (51.8)
ALP (U/L) 317 (207–416) 315 (250–423) 320 (200–385)
  > URR 80 (53.3) 37 (55.2) 43 (51.8)
GGT (U/L) 29 (19–48) 29 (21–47) 29 (18–52)
  > URR 30 (20.0) 14 (20.9) 16 (19.3)
Total bilirubin (μmol/L) 19 (10–38) 21 (12–51) 17 (10–31)
  > URR 36 (24.0) 20 (29.9) 16 (19.3)
Albumin (g/L) 37 (28–50) 36 (30–50) 37 (27–50)
  < LRR 63 (42.0) 27 (40.3) 36 (43.4)
Creatinine (μmol/L) 80 (62–97) 80 (62–97) 71 (62–88)
  > URR 23 (15.3) 11 (16.4) 12 (14.5)
  < LRR 19 (12.7) 8 (11.9) 11 (13.3)
Platelet count (109/L) 125 (76–206) 123 (71–186) 147 (76–223)
  < LRR 75 (50.0) 36 (53.7) 39 (47.0)
IgG (g/L) 23.9 (17.1–32.5) 27.0 (16.7–34.2) 21.6 (17.2–30.6)
  > URR 55 (36.7) 31 (46.3) 24 (28.9)
HIV infectiona 4 (2.7) 1 (1.5) 3 (3.6)
Kato-Katz smear positive 23 (16.5)b 13 (21.3)c 10 (12.8)d
APRI score > 0.7e 92 (61.7)f 46 (69.7)f 46 (55.4)
FIB-4 score > 3.25g 43 (28.9)f 20 (30.3)f 23 (27.7)
APRI score > 0.7 OR
FIB-4 score > 3.25
94 (63.1)f 46 (69.7)f 48 (57.8)
  1. Data are presented as number (%) or as median (interquartile range)
  2. Laboratory reference ranges: ALT (8–40 U/L); AST (14–40 U/L); ALP (60–306 U/L); GGT (7–61 U/L); Bilirubin (3–38 μmol/L); Albumin (35–52 g/L); Creatinine (47–109 μmol/L); Platelet count (126–438 × 109/L); IgG (0.8–27.8 g/L) [21]
  3. aOne patient with chronic HCV was co-infected with HIV.
  4. bStool sample missing in 11 patients.
  5. cStool sample missing in six patients.
  6. dStool sample missing in five patients.
  7. eAPRI: (AST (U/L)/URR of AST (U/L))/platelet count (109/L) × 100
  8. fOne observation missing.
  9. gFIB-4: age (years) x AST (U/L)/(platelet count (109/L) x √ALT (U/L))
  10. *p < 0.05; significance of the difference between the aetiology known/unknown group
  11. Abbreviations: ALP alkaline phosphatase, ALT alanine aminotransferase, APRI aspartate aminotransferase to platelets ratio index, AST aspartate aminotransferase, GGT gamma-glutamyltransferase, HCV hepatitis C virus, HIV human immunodeficiency virus, IgG immunoglobulin G, LRR lower reference range, URR upper reference range