APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism

BMC Gastroenterology

Table 2 Association of SNP genotype with HCV infection

		Alleles	HCV	Overall genotype distribution(n)			P-value	Comparison of specific genotypes	P-value
		Alleles	HCV	Overall genotype distribution(n)			(χ2 value)	Comparison of specific genotypes	(χ2 value)
APOA1	rs613808	G/A		AA	GA	GG
			+	72	74	12	0.192
			–	120	83	17	(3.297)
	rs2727784	G/A		GG	GA	AA
			+	75	71	12	0.290
			–	122	82	16	(2.473)
	rs11216158	A/G		GG	AG	AA
			+	99	56	3	0.231
			–	150	62	8	(2.933)
APOB	rs676210	C/T		TT	CT	CC
			+	88	57	13	0.091	TT + CT vs CC	0.031
			–	133	80	7	(4.784)		(4.673)
	rs1042031	G/A		GG	GA	AA
			+	150	8	0
			–	205	15	0
	rs693	C/T		CC	CT	TT
			+	147	11	0
			–	199	21	0
	rs1801701	G/A		GG	GA	AA
			+	158	0	0
			–	220	0	0
	rs1042034	A/G		GG	AG	AA
			+	88	57	13	0.051	GG + AG vs AA	0.016
			–	134	80	6	(5.963)		(5.828)
SR-B1	rs4238001	G/A		GG	GA	AA
			+	157	1	0
			–	220	0	0
	rs61932577	C/T		CC	CT	TT
			+	158	0	0
			–	220	0	0
	rs5888	C/T		CC	CT	TT
			+	96	54	10	0.761
			–	128	82	10	(0.546)
LDLR	rs17249134	T/G		GG	TG	TT
			+	158	0	0
			–	220	0	0
	rs17249141	T/C		CC	TC	TT
			+	158	0	0
			–	220	0	0
	rs2228671	C/T		CC	CT	TT
			+	156	2	0
			–	219	1	0
	rs11669576	A/G		GG	AG	AA
			+	158	0	0
			–	220	0	0
	rs5930	G/A		GG	GA	AA
			+	66	73	19	0.957
			–	89	105	26	(0.088)
	rs688	T/C		CC	TC	TT
			+	120	36	2	0.664
			–	160	55	5	(0.820)
	rs5925	C/T		TT	CT	CC
			+	114	42	2	0.479
			–	149	65	6	(1.472)
	rs2569542	A/G		GG	AG	AA
			+	138	19	1	0.935
			–	190	28	2	(0.135)
	rs14158	G/A		GG	GA	AA
			+	58	75	25	0.928
			–	84	100	36	(0.150)
APOE	rs429358	T/C		TT	TC	CC
			+	131	27	0	0.564
			–	177	41	2	(0.333)
	rs7412	C/T		CC	CT	TT
			+	142	16	0
			–	196	24	0

ISSN: 1471-230X